Department of Biomedical Engineering, University of Southern California, Los Angeles, California.
Biomedical Simulations Resource Center, University of Southern California, Los Angeles, California.
Brain Behav. 2019 Aug;9(8):e01356. doi: 10.1002/brb3.1356. Epub 2019 Jul 9.
To compare the novel model-based hemodynamic physiomarker of Dynamic Vasomotor Reactivity (DVR) with biomarkers based on Diffusion Tensor Imaging (DTI) and some widely used neurocognitive scores in terms of their ability to delineate patients with amnestic Mild Cognitive Impairment (MCI) from age-matched cognitively normal controls.
MATERIALS & METHODS: The model-based DVR and MRI-based DTI markers were obtained from 36 patients with amnestic MCI and 16 age-matched controls without cognitive impairment, for whom widely used neurocognitive scores were available. These markers and scores were subsequently compared in terms of statistical delineation between patients and controls.
It was found that statistically significant delineation between MCI patients and controls was comparable for DVR or DTI markers (p < 0.01). The performance of both types of markers was consistent with the scores of some (but not all) widely used neurocognitive tests.
Since DTI offers a measure of cerebral white matter integrity, the results suggest that the model-based hemodynamic marker of DVR may correlate with cognitive impairment due to white matter lesions. This finding is consistent with the hypothesis that dysregulation of cerebral microcirculation may be an early cause of cognitive impairment, which has been recently corroborated by several studies.
比较基于新型模型的血流动力学生理标志物动态血管运动反应（DVR）与基于弥散张量成像（DTI）的生物标志物以及一些广泛使用的神经认知评分，以评估它们在区分遗忘型轻度认知障碍（MCI）患者与年龄匹配的认知正常对照方面的能力。
从 36 名遗忘型 MCI 患者和 16 名年龄匹配的无认知障碍的认知正常对照中获得基于模型的 DVR 和基于 MRI 的 DTI 标志物，这些对照者均具有广泛使用的神经认知评分。随后比较这些标志物和评分在患者与对照组之间的统计学区分能力。
发现 DVR 或 DTI 标志物在统计学上可很好地区分 MCI 患者与对照组（p<0.01）。这两种类型标志物的性能与一些（但不是全部）广泛使用的神经认知测试的评分一致。
由于 DTI 提供了脑白质完整性的测量，因此结果表明，基于模型的血流动力学 DVR 标志物可能与白质病变引起的认知障碍相关。这一发现与大脑微循环失调可能是认知障碍的早期原因的假设一致，最近有几项研究证实了这一假设。
