Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand.
Exercise Physiology Laboratory, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
BMC Complement Altern Med. 2019 Jul 8;19(1):165. doi: 10.1186/s12906-019-2579-4.
Rosmarinic acid (RA) is a natural pure compound from herbs belonging to the Lamiaceae family, such as rosemary, sage, basil, and mint. The antioxidant, angiotensin-converting enzyme inhibitory, and vasodilatory effects of RA have been revealed. Angiotensin II (ANG II) is a potent agent that generates hypertension and oxidative stress. Hypertension and skeletal muscle insulin resistance are strongly related. The aim of this study was to evaluate the effects of acute and chronic RA treatment on blood pressure and skeletal muscle glucose transport in ANG II-induced hypertensive rats.
Eight-week-old male Sprague Dawley rats were separated into SHAM and ANG II-infused (250 ng/kg/min) groups. ANG II rats were treated with or without acute or chronic RA at 10, 20, or 40 mg/kg. At the end of the experiment, body weight, liver and heart weights, oral glucose tolerance, skeletal muscle glucose transport activity, and signaling proteins were evaluated.
Both acute and chronic RA treatment decreased systolic, diastolic, and mean arterial blood pressure. Only acute RA at 40 mg/kg resulted in a reduction of fasting plasma glucose levels and an induction of skeletal muscle glucose transport activity. These effects might involve increased ERK activity in skeletal muscle. Meanwhile, chronic RA treatment with 10, 20, and 40 mg/kg prevented ANG II-induced hyperglycemia.
Both acute and chronic RA treatment attenuated ANG II-induced cardiometabolic abnormalities in rats. Therefore, RA would be an alternative strategy for improving skeletal muscle glucose transport and protecting against ANG II-induced hypertension and hyperglycemia.
迷迭香酸（RA）是一种天然的纯化合物，来源于唇形科的草药，如迷迭香、鼠尾草、罗勒和薄荷。已经揭示了 RA 的抗氧化、血管紧张素转换酶抑制和血管舒张作用。血管紧张素 II（ANG II）是一种产生高血压和氧化应激的有效物质。高血压和骨骼肌胰岛素抵抗密切相关。本研究旨在评估急性和慢性 RA 治疗对 ANG II 诱导的高血压大鼠血压和骨骼肌葡萄糖转运的影响。
将 8 周龄雄性 Sprague Dawley 大鼠分为 SHAM 和 ANG II 输注（250ng/kg/min）组。ANG II 大鼠分别用或不用 10、20 或 40mg/kg 的急性或慢性 RA 处理。在实验结束时，评估体重、肝重和心脏重、口服葡萄糖耐量、骨骼肌葡萄糖转运活性和信号蛋白。
急性和慢性 RA 治疗均降低收缩压、舒张压和平均动脉压。只有急性 RA 40mg/kg 降低了空腹血糖水平并诱导了骨骼肌葡萄糖转运活性。这些作用可能涉及骨骼肌中 ERK 活性的增加。同时，10、20 和 40mg/kg 的慢性 RA 治疗可预防 ANG II 诱导的高血糖。
急性和慢性 RA 治疗均可减轻 ANG II 诱导的大鼠心脏代谢异常。因此，RA 可能是改善骨骼肌葡萄糖转运和预防 ANG II 诱导的高血压和高血糖的一种替代策略。
