El Midaoui Adil, Khallouki Farid, Couture Réjean, Moldovan Florina, Ismael Mahmoud Ali, Ongali Brice, Akoume Marie Yvonne, Alem Chakib, Ait Boughrous Ali, Zennouhi Wafa, Roqai Mhammed Chaoui, Hajji Lhoussain, Ghzaiel Imen, Vejux Anne, Lizard Gérard
Department of Pharmacology and Physiology, Faculty of Medicine, University of Montreal, Montreal, QC H3C 3J7, Canada.
Department of Biology, Faculty of Sciences and Techniques, Errachidia, Moulay Ismail University of Meknes, Meknes 50050, Morocco.
Nutrients. 2023 Sep 21;15(18):4077. doi: 10.3390/nu15184077.
(Lamiaceae) is a plant endemic to the Mediterranean basin that is found in significant quantities in the arid regions of Morocco. is used in traditional medicine to treat infectious and non-infectious diseases. It is also used for the isolation of essential oils and for the seasoning of many dishes in the Mediterranean diet. The major constituents of are saponins, flavonoids, tannins, alkaloids, various simple and hydroxycinnamic phenolic compounds, and terpene compounds. Several of these compounds act on signaling pathways of oxidative stress, inflammation, and blood sugar, which are parameters often dysregulated during aging. Due to its physiochemical characteristics and biological activities, could be used for the prevention and/or treatment of age-related diseases. These different aspects are treated in the present review, and we focused on phytochemistry and major age-related diseases: dyslipidemia, cardiovascular diseases, and type 2 diabetes.
（唇形科）是一种地中海盆地特有的植物，在摩洛哥的干旱地区大量存在。它在传统医学中用于治疗感染性和非感染性疾病。它还用于分离精油以及在地中海饮食中为许多菜肴调味。其主要成分包括皂苷、黄酮类化合物、单宁、生物碱、各种简单和羟基肉桂酸酚类化合物以及萜类化合物。这些化合物中的几种作用于氧化应激、炎症和血糖的信号通路，而这些参数在衰老过程中常常失调。由于其理化特性和生物活性，它可用于预防和/或治疗与年龄相关的疾病。本综述探讨了这些不同方面，并且我们重点关注了植物化学以及主要的与年龄相关的疾病：血脂异常、心血管疾病和2型糖尿病。
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