Institute of Biology of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia.
Int J Radiat Biol. 2019 Nov;95(11):1564-1572. doi: 10.1080/09553002.2019.1642534. Epub 2019 Jul 22.
The role of transposable elements in formation of radiobiological effects is understudied and contradictory. The aim of this study was to investigate the response of to irradiation depending on the level of activity transposons and the role of transposons in formation of ionizing radiation late effects. The individuals of with different level activity of -elements were exposed to acute irradiation in doses of 1-100 Gy at early ontogenesis stages. The reaction of individuals to exposure was studied using the larvae survival rate, morphological parameters of reproduction system, DNA damage rate, and mutability of locus. We found the pronounced linear deferred effects of irradiation for animals with a high activity level of full-size copies. The radiosensitivity of individuals with a mean level of activity transposon was whether higher or did not differ from the radiosensitivity of animals with a low activity . The obtained results suggest that full-size -elements with a high activity level (less often with a mean activity level) are responsible for delayed deleterious irradiation effects.
转座元件在放射生物学效应形成中的作用尚未得到充分研究，且结果相互矛盾。本研究旨在探讨转座元件活性水平与 对辐射的反应，以及转座元件在形成电离辐射晚期效应中的作用。不同转座元件活性水平的 在早期胚胎发生阶段接受 1-100Gy 的急性照射。通过幼虫存活率、生殖系统形态参数、DNA 损伤率和 位点突变率来研究个体对暴露的反应。我们发现高拷贝全长 活性水平的动物存在明显的线性延迟辐射效应。具有中等转座元件活性水平的个体的辐射敏感性要么高于、要么与低活性 动物的辐射敏感性没有差异。研究结果表明，高活性水平（较少情况下为中等活性水平）的全长 -元件负责延迟的有害辐射效应。
