Department of Otorhinolaryngology, Sakarya University School of Medicine, Sakarya, Turkey.
Department of Biostatistics, Sakarya University School of Medicine, Sakarya, Turkey.
J Int Adv Otol. 2020 Apr;16(1):47-52. doi: 10.5152/iao.2019.5415.
This study evaluated the efficacy of intratympanic steroid injection (ITSI)as initial treatment and therecovery speed for Bell's palsy (BP)inpatients with diabetes mellitus (DM)and/or hypertension (HT).
In total,90 patients with comorbid diseases diagnosed with BP received either ITSI (study group, n=61) or systemic steroid treatment (SST) (control group, n=29).The facial nerve function was assessed using the House-Brackmann (HB) grading system for up to 6 months or until complete recovery from BP. To investigate a relationship with the complete recovery time from BP, hematologic and baseline characteristic parameters were analyzed.
The complete recovery rate of the ITSI and SST groups was 47.5% and 44.8% at the 1st month, 70.5% and 89.7% at the 3rd month, and 96.7% and 100% at the 6th month of the study, respectively. Lymphocyte and neutrophil values were significantly associated with the complete recovery time from BP. No major adverse events from ITSI itself were noticed during the procedure and during the follow-up of the treatment.
Both treatment types have no superiorities over each other in initial treatment for BP in patients with comorbid diseases. ITSI is effective and safe and may avoid the unwanted side effects associated with systemic steroids inthese patients.
本研究评估了鼓室内类固醇注射（ITSI）作为糖尿病（DM）和/或高血压（HT）合并贝尔麻痹（BP）患者初始治疗的疗效以及恢复速度。
共 90 例患有合并症的 BP 患者接受 ITIS（研究组，n=61）或全身类固醇治疗（SST）（对照组，n=29）。采用 House-Brackmann（HB）分级系统评估面神经功能，最长 6 个月或直至 BP 完全恢复。为了研究与 BP 完全恢复时间的关系，分析了血液学和基线特征参数。
第 1 个月，ITSI 和 SST 组的完全恢复率分别为 47.5%和 44.8%，第 3 个月分别为 70.5%和 89.7%，第 6 个月分别为 96.7%和 100%。淋巴细胞和中性粒细胞值与 BP 的完全恢复时间显著相关。在治疗过程中和治疗随访期间，未发现 ITIS 本身有任何重大不良事件。
对于合并症患者的 BP 初始治疗，两种治疗方法均无优势。ITSI 有效且安全，可避免此类患者全身类固醇相关的不良作用。
