抗病毒药物联合皮质类固醇治疗急性特发性面神经麻痹（贝尔麻痹）成人的早期治疗。
Antiviral Agents Added to Corticosteroids for Early Treatment of Adults With Acute Idiopathic Facial Nerve Paralysis (Bell Palsy).
机构信息
UTOPIAN FMTU, North York General Hospital, Toronto, Ontario, Canada2Department of Family and Community Medicine and Dalla Lana School of Public Health, University of Toronto, Ontario, Canada3Scientist Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Frontier Science Ltd, Grampian View, Scotland.
出版信息
JAMA. 2016;316(8):874-5. doi: 10.1001/jama.2016.10160.
CLINICAL QUESTION
Compared with oral corticosteroids alone, are oral antiviral drugs associated with improved outcomes when combined with oral corticosteroids in patients presenting within 72 hours of the onset of Bell palsy?
BOTTOM LINE
Compared with oral corticosteroids alone, the addition of acyclovir, valacyclovir, or famcyclovir to oral corticosteroids for treatment of Bell palsy was associated with a higher proportion of people who recovered at 3- to 12-month follow-up. The quality of evidence is limited by heterogeneity, imprecision of the result estimates, and risk of bias.
临床问题
与单独使用口服皮质类固醇激素相比，在发病后 72 小时内使用阿昔洛韦、伐昔洛韦或泛昔洛韦联合口服皮质类固醇激素治疗贝尔面瘫的患者，联合治疗是否比单独使用口服皮质类固醇激素的结局更好？
结论
与单独使用口服皮质类固醇激素相比，在治疗贝尔面瘫时，阿昔洛韦、伐昔洛韦或泛昔洛韦联合口服皮质类固醇激素治疗与更高比例的患者在 3 至 12 个月的随访中恢复相关。证据质量受到异质性、结果估计不精确和偏倚风险的限制。
Zotero 插件