钌树状大分子对抗急性早幼粒细胞白血病：对 HL-60 细胞的研究。

Ruthenium dendrimers against acute promyelocytic leukemia: studies on HL-60 cells.

机构信息

Laboratory of Microscopic Imaging & Specialized Biological Techniques, Faculty of Biology & Environmental Protection, University of Lodz, Banacha12/16, Lodz 90-237, Poland.

Department of General Biophysics, Faculty of Biology & Environmental Protection, University of Lodz, Pomorska 141/143, Lodz 90-236, Poland.

出版信息

Future Med Chem. 2019 Jul;11(14):1741-1756. doi: 10.4155/fmc-2018-0274. Epub 2019 Jul 9.

DOI:10.4155/fmc-2018-0274

PMID:31287722

Abstract

Coordination of ruthenium arene fragments on carbosilane dendrimers' surface greatly increases their antitumor properties. Newly synthetized ruthenium dendrimers are water-soluble, monodisperse and stable. Since carbosilane dendrimers are good carriers of drugs and genes, the presence of ruthenium in their structure makes them promising candidates for new drug delivery systems with improved antitumor potential. Carbosilane ruthenium dendrimers are more toxic to cancer cells than normal cells. Results of several studies applied here indicate that carbosilane ruthenium dendrimers induce apoptosis in promyelocytic leukemia HL-60 cells.

摘要

芳基金属钌片段在碳硅烷树枝状大分子表面的配位极大地提高了它们的抗肿瘤特性。新合成的钌树枝状大分子具有水溶性、单分散性和稳定性。由于碳硅烷树枝状大分子是药物和基因的良好载体，其结构中存在钌使它们成为具有改进的抗肿瘤潜力的新型药物输送系统的有前途的候选物。碳硅烷钌树枝状大分子对癌细胞比对正常细胞更具毒性。这里应用的几项研究的结果表明，碳硅烷钌树枝状大分子诱导早幼粒细胞白血病 HL-60 细胞凋亡。