The Nightingale Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Southmoor Road, Manchester, M23 9LT, UK.
James Paget University Hospitals NHS Foundation Trust, Lowestoft Road, Gorleston-on-Sea, Great Yarmouth, NR31 6LA, UK.
Eur J Surg Oncol. 2019 Nov;45(11):2016-2021. doi: 10.1016/j.ejso.2019.06.035. Epub 2019 Jun 26.
Magseed is an alternative method of localising non-palpable breast lesions that has addressed many of the limitations of wire guided localisation (WGL). It consists of a paramagnetic seed that can be visualised on mammography and ultrasound. Intraoperative localisation of the seed is achieved with the use of the Sentimag probe. The aim of this study was to prospectively compare localisation in patients undergoing wide local excision (WLE) for non-palpable lesions between Magseed and WGL.
We prospectively collected data on all patients undergoing image-guided WLE between October 2017 and September 2018 in two academic breast units with a planned accrual of 100 consecutive patients undergoing Magseed localisation. Data was also collected on a cohort of 100 consecutive patients undergoing WGL in the same time period.
Demographic and disease characteristics were well balanced between the two groups. 4/104 patients were converted preoperatively from Magseed to WGL (2 misplaced Magseeds; 2 undetected Magseeds). Intraoperative identification and excision of the localised lesion was successful in all patients as confirmed with specimen radiography. Overall no significant differences were observed in the proportion of patients requiring re-excision between the two groups (Magseed 16% vs. WGL 14% p = 0.692). Specimens size by weight and volume was similar for both groups (Magseed 39.6 g vs. WGL 44.5 g p = 0.206 and 90.1 cm for Magseed vs. 95.6 cm for WGL p = 0.579).
In our series Magseed localisation proved to be as reliable and effective as WGL in terms of lesion identification, excision with tumour free margins and specimen weight.
Magseed 是一种替代方法，用于定位不可触及的乳房病变，它解决了许多金属丝引导定位（WGL）的局限性。它由一个顺磁性种子组成，可以在乳房 X 光片和超声中看到。术中通过使用 Sentimag 探头定位种子。本研究的目的是前瞻性比较不可触及病变行广泛局部切除术（WLE）的患者中 Magseed 和 WGL 定位的效果。
我们前瞻性地收集了 2017 年 10 月至 2018 年 9 月期间在两个学术乳房单位接受影像引导 WLE 的所有患者的数据，计划招募 100 例连续接受 Magseed 定位的患者。同时还收集了同期 100 例连续接受 WGL 患者的数据。
两组患者的人口统计学和疾病特征平衡良好。有 4/104 例患者术前从 Magseed 改为 WGL（2 例 Magseed 定位错误；2 例 Magseed 未检出）。所有患者均成功进行了术中识别和切除定位的病变，并通过标本放射照相术确认。总体而言，两组患者中需要再次切除的患者比例无显著差异（Magseed 组 16%，WGL 组 14%，p=0.692）。两组标本的重量和体积相似（Magseed 组 39.6g，WGL 组 44.5g，p=0.206；Magseed 组 90.1cm3，WGL 组 95.6cm3，p=0.579）。
在我们的系列研究中，Magseed 定位在病灶识别、无肿瘤切缘的切除和标本重量方面与 WGL 一样可靠和有效。
