硬皮病中的内皮损伤。
Endothelial injury in scleroderma.
作者信息
Kahaleh M B, Sherer G K, LeRoy E C
出版信息
J Exp Med. 1979 Jun 1;149(6):1326-35. doi: 10.1084/jem.149.6.1326.
Abstract
Functional and structural vascular lesions have been observed in the organs involved in scleroderma. The etiology of these vascular changes is poorly understood. The ability to isolate, characterize, and maintain endothelial cells in vitro provides a target cell population to study endothelial damage in scleroderma. The present report describes the effect of scleroderma serum on endothelial, smooth muscle, and fibroblast cell types. Sera from patients with scleroderma (31/52) and Raynaud's syndrome (11/19) contain cytotoxic activity, specific for endothelial cells, which is nondialyzable, heat-stable, and elutes with albumin on gel-filtration chromatography.
摘要
在硬皮病累及的器官中已观察到功能性和结构性血管病变。这些血管变化的病因尚不清楚。体外分离、鉴定和维持内皮细胞的能力为研究硬皮病中的内皮损伤提供了一个靶细胞群体。本报告描述了硬皮病血清对内皮细胞、平滑肌细胞和成纤维细胞类型的影响。硬皮病患者（31/52）和雷诺综合征患者（11/19）的血清含有对内皮细胞具有特异性的细胞毒性活性，该活性不可透析、热稳定，并且在凝胶过滤色谱上与白蛋白一起洗脱。
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