Institute of Life Sciences, Jiangsu University, Zhenjiang, China.
Arch Insect Biochem Physiol. 2019 Sep;102(1):e21598. doi: 10.1002/arch.21598. Epub 2019 Jul 9.
At present, the effect of ultraviolet (UV) radiation on the interaction between Bombyx mori nucleopolyhedrovirus (BmNPV) and host remains unclear. In the current study, UV treatment significantly reduced the activity of BmNPV budded viruses (BVs), and UV-damaged BmN cells were not conducive to BmNPV proliferation. BmNPV infection significantly reduced the viability of host cells, but increased the viability of high-dose UV-treated host cells. Furthermore, the quantitative reverse-transcription PCR (qPCR) results suggested that BmNPV and Bombyx mori might mutually use the same DNA repair proteins for repairing UV-induced damage and BmNPV infection promote the ability of host cells to repair UV-induced damage.
目前，紫外线（UV）辐射对家蚕核型多角体病毒（BmNPV）与宿主之间相互作用的影响尚不清楚。在本研究中，UV 处理显著降低了 BmNPV 出芽病毒（BVs）的活性，并且 UV 损伤的 BmN 细胞不利于 BmNPV 的增殖。BmNPV 感染显著降低了宿主细胞的活力，但增加了高剂量 UV 处理的宿主细胞的活力。此外，定量逆转录 PCR（qPCR）结果表明，BmNPV 和家蚕可能相互利用相同的 DNA 修复蛋白来修复 UV 诱导的损伤，并且 BmNPV 感染促进了宿主细胞修复 UV 诱导损伤的能力。
