Steis R G, Marcon L, Clark J, Urba W, Longo D L, Nelson D L, Maluish A E
Division of Cancer Treatment, National Cancer Institute, Frederick, MD 21701.
Blood. 1988 May;71(5):1304-9.
Activated T cells synthesize and express a cell membrane-bound receptor for interleukin-2 (IL-2) and have recently been shown to secrete a soluble form of the same receptor. Hairy cell leukemia is a chronic disorder caused by expansion of a clonal population of an unusual mononuclear cell of B cell origin. These cells have previously been shown to express an IL-2 receptor on the cell membrane. The sera of 26 patients with hairy cell leukemia were examined for the presence of a soluble IL-2 receptor before and during therapy with either recombinant interferon alpha-2a or 2'-deoxycoformycin. Before therapy, all patients had markedly elevated levels of this soluble IL-2 receptor ranging from five to 60 times the highest level observed in normal control sera. In individual patients changes in the level during therapy correlated well with clinical assessments of tumor response; levels fell to near the normal range in patients responding to therapy. Patients not responding to interferon alpha had no significant change in the soluble IL-2 receptor level. These results suggest that hairy cells secrete a soluble IL-2 receptor and that serial measurements of the level of this receptor in the serum can be used as a noninvasive means to assess disease response to therapy.
活化的T细胞合成并表达白细胞介素-2（IL-2）的细胞膜结合受体，最近还显示它们能分泌相同受体的可溶性形式。毛细胞白血病是一种由B细胞来源的异常单核细胞的克隆群体扩增引起的慢性疾病。这些细胞先前已被证明在细胞膜上表达IL-2受体。在使用重组干扰素α-2a或2'-脱氧助间型霉素治疗之前和治疗期间，检测了26例毛细胞白血病患者血清中可溶性IL-2受体的存在情况。治疗前，所有患者的这种可溶性IL-2受体水平均显著升高，范围是正常对照血清中观察到的最高水平的5至60倍。在个体患者中，治疗期间水平的变化与肿瘤反应的临床评估密切相关；对治疗有反应的患者，其水平降至接近正常范围。对干扰素α无反应患者的可溶性IL-2受体水平无显著变化。这些结果表明，毛细胞分泌可溶性IL-2受体，并且血清中该受体水平的系列测量可作为评估疾病对治疗反应的一种非侵入性手段。
