Wu Yan-Chen, Jiang Shuai-Shuai, Luo Shu-Zheng, Song Ren-Jie, Li Jin-Heng
Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang 330063, China.
Chem Commun (Camb). 2019 Aug 7;55(61):8995-8998. doi: 10.1039/c9cc03789f. Epub 2019 Jul 10.
A new, practical directed anodic C-H sulfonylation of N,N-disubstituted anilines with sodium sulfinates for producing o- or p-amino arylsulfones and diarylsulfones is described. Employing the anodic strategy, the reaction proceeds efficiently under mild (room temperature) and transition-metal- and chemical oxidant-free conditions, and enables the formation of C-S bonds via directed activation of ortho- or para-C-H bond to the amino group with broad substrate scope and excellent site selectivity.
本文描述了一种新型、实用的以亚磺酸钠对N,N-二取代苯胺进行直接阳极C-H磺酰化反应，用于制备邻位或对位氨基芳基砜和二芳基砜。采用阳极策略，该反应在温和（室温）、无过渡金属和无化学氧化剂的条件下高效进行，通过将氨基邻位或对位的C-H键定向活化实现C-S键的形成，底物范围广泛，位点选择性优异。
