Laboratorio de Genotoxicología y Medicina Ambientales, Departamento de Ciencias Ambientales, Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, Ciudad de México, México.
Departamento de Fisiología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México, México.
PLoS One. 2019 Jul 10;14(7):e0218198. doi: 10.1371/journal.pone.0218198. eCollection 2019.
Bisphenol A (BPA) is an endocrine disruptor compound with estrogenic activity, possessing affinity for both nuclear (ERα and ERβ) and membrane estrogen receptors. The main source of BPA exposure comes from the contamination of food and water by plastic storage containers or disposable bottles, among others, in which case BPA is easily ingested. Exposure to BPA during early pregnancy leads to lifelong effects; however, its effect on the immune system has not been fully studied. Since endocrine and immune systems interact in a bidirectional manner, the disruption of the former may cause permanent alterations of the latter, thus affecting a future anti-parasitic response. In this study, neonate BALB/c mice were exposed to a single dose of BPA (250 μg/kg); once sexual maturity was reached, they were orally infected with Trichinella spiralis (T. spiralis). The analyses performed after 5 days of infection revealed a decreased parasitic load in the duodenum of mice in the BPA-treated group. Flow cytometry analyses also revealed changes in the immune cell subpopulations of the infected animals when compared to the BPA-treated group. RT-PCR analyses of duodenum samples showed an increased expression of TNF-α, IFN-γ, IL-4, IL-5, and IL-9 in the BPA-treated group. These findings show a new aspect whereby early-life exposure to BPA contributes to the protection against T. spiralis by modulating the anti-parasitic immune response.
双酚 A（BPA）是一种具有雌激素活性的内分泌干扰化合物，对核（ERα和 ERβ）和膜雌激素受体均具有亲和力。BPA 的主要暴露源来自于塑料储存容器或一次性瓶子等对食物和水的污染，在这种情况下，BPA 很容易被摄入。在妊娠早期接触 BPA 会导致终身影响；然而，其对免疫系统的影响尚未得到充分研究。由于内分泌系统和免疫系统以双向方式相互作用，前者的破坏可能导致后者的永久性改变，从而影响未来的抗寄生虫反应。在这项研究中，新生 BALB/c 小鼠接受了单次 BPA（250 μg/kg）暴露；一旦达到性成熟，它们就会经口感染旋毛虫（T. spiralis）。感染后 5 天进行的分析显示，BPA 处理组小鼠十二指肠中的寄生虫负荷减少。与 BPA 处理组相比，感染动物的免疫细胞亚群的流式细胞术分析也显示出变化。对十二指肠样本的 RT-PCR 分析显示，BPA 处理组 TNF-α、IFN-γ、IL-4、IL-5 和 IL-9 的表达增加。这些发现表明，早期生活中接触 BPA 通过调节抗寄生虫免疫反应有助于保护旋毛虫。
