Sandoval Juan de Jesus, Turra Cassio Maldonado, Loschi Rosangela Helena
Escuela de Nutrición y Dietética, Universidad de Antioquia, Antioquia, Colombia.
Centro de Desenvolvimento e Planejamento Regional, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Cad Saude Publica. 2019 Jul 4;35(6):e00091918. doi: 10.1590/0102-311X00091918.
This paper provides estimates of mortality rates from Alzheimer's disease dementia (AD) in the elderly Brazilian population. Data were obtained from the 2010 Population Census by Brazilian Institute of Geography and Statistics (IBGE) and microdata on mortality in Brazil's 27 state capitals recorded in the Brazilian Mortality Information System (SIM) for the population 65 years or older by place of residence for the years 2009 to 2013. Corrections were obtained for underreporting of mortality, and final adjustments were made to the specific mortality rates based on Bayesian methods with prior probability distributions built on the basis of information obtained from a meta-analysis. The mortality rates from all dementias and from AD in Brazil were higher than in developed countries. The mortality rates from Alzheimer's disease in 2013 were 140.03 (95%CI: 117.05; 166.4) and 127.07 (95%CI: 103.74; 149.62) per 100,000 inhabitants, respectively, in men and women. The contribution of AD to mortality in elderly Brazilians was 4.4% (95%CI: 3.25; 5.72) in the group with 0 to 3 years of schooling, independently of age and sex. The study aimed to increase knowledge on corrected estimates of mortality rates from Alzheimer's disease based on vital statistics, providing more precise and pertinent evidence-based estimates.
本文提供了巴西老年人群中阿尔茨海默病性痴呆（AD）死亡率的估计值。数据来自巴西地理与统计研究所（IBGE）的2010年人口普查，以及巴西死亡率信息系统（SIM）记录的2009年至2013年巴西27个州首府65岁及以上居民按居住地划分的微观死亡数据。对死亡率报告不足进行了校正，并基于贝叶斯方法对特定死亡率进行了最终调整，其先验概率分布是根据从一项荟萃分析中获得的信息构建的。巴西所有痴呆症和AD的死亡率均高于发达国家。2013年，男性和女性中阿尔茨海默病的死亡率分别为每10万居民140.03（95%CI：117.05；166.4）和127.07（95%CI：103.74；149.62）。在受教育年限为0至3年的人群中，无论年龄和性别，AD对巴西老年人死亡率的贡献为4.4%（95%CI：3.25；5.72）。该研究旨在增加基于人口动态统计数据的阿尔茨海默病死亡率校正估计值的知识，提供更精确和相关的循证估计。
