Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA, 30322, USA.
Paul Scherrer Institut, 5232, Villigen, PSI, Switzerland.
Angew Chem Int Ed Engl. 2019 Sep 16;58(38):13507-13512. doi: 10.1002/anie.201906214. Epub 2019 Aug 12.
The successful integration of 2D nanomaterials into functional devices hinges on developing fabrication methods that afford hierarchical control across length scales of the entire assembly. We demonstrate structural control over a class of crystalline 2D nanosheets assembled from collagen triple helices. By lengthening the triple helix unit through sequential additions of Pro-Hyp-Gly triads, we achieved sub-angstrom tuning over the 2D lattice. These subtle changes influence the overall nanosheet size, which can be adjusted across the mesoscale size regime. The internal structure was observed by cryo-TEM with direct electron detection, which provides real-space high-resolution images, in which individual triple helices comprising the lattice can be clearly discerned. These results establish a general strategy for tuning the structural hierarchy of 2D nanomaterials that employ rigid, cylindrical structural units.
将二维纳米材料成功整合到功能器件中，关键在于开发制造方法，以便在整个组装体的各个长度尺度上实现层次控制。我们展示了对一类由胶原蛋白三螺旋组装而成的结晶二维纳米片的结构控制。通过连续添加脯氨酸-羟脯氨酸-甘氨酸三肽来延长三螺旋单元，我们实现了对二维晶格的亚埃级调谐。这些细微的变化影响了整个纳米片的尺寸，可以在介观尺寸范围内进行调节。通过使用直接电子检测的 cryo-TEM 观察到内部结构，该方法提供了实空间高分辨率图像，其中可以清楚地分辨出构成晶格的单个三螺旋。这些结果为使用刚性圆柱形结构单元的二维纳米材料的结构层次调控建立了一种通用策略。
