Senut M C, Roudier M, Davous P, Fallet-Bianco C, Lamour Y
Unité de Recherches de Neurophysiologie Pharmacologique, I.N.S.E.R.M., U. n. 161, Paris.
C R Acad Sci III. 1988;306(6):221-7.
Senile plaques (SP) are one of the major neuropathologic hallmarks of senile dementia of Alzheimer type (SDAT). The regional distribution of SP stained for acetylcholinesterase (AChE) has been quantified in the hippocampal formation of patients with SDAT. Consistent differences in plaque distribution and density were observed between different patients. SP were significantly more numerous in the outer dentate molecular layer, whereas their density was low in other hippocampal regions. The quantity of AChE positive SP seemed to correlate with the density of neurofibrillary tangles in the entorhinal cortex. The AChE positive SP had a pattern of distribution different from the one observed with Thioflavin S. These results are discussed in light of a possible sprouting of cholinergic septal afferents.
老年斑（SP）是阿尔茨海默型老年痴呆症（SDAT）的主要神经病理学特征之一。已对SDAT患者海马结构中经乙酰胆碱酯酶（AChE）染色的SP的区域分布进行了量化。在不同患者之间观察到斑块分布和密度存在一致差异。外齿状分子层中的SP明显更多，而在其他海马区域其密度较低。AChE阳性SP的数量似乎与内嗅皮质中神经原纤维缠结的密度相关。AChE阳性SP的分布模式与用硫黄素S观察到的不同。根据胆碱能隔区传入纤维可能的发芽对这些结果进行了讨论。
