Senut M C, Roudier M, Davous P, Fallet-Bianco C, Lamour Y
Laboratoire de Physiopharmacologie du Système Nerveux, INSERM U161, Paris, France.
Acta Neuropathol. 1991;82(4):306-15. doi: 10.1007/BF00308817.
Senile plaques (SP) are one of the neuropathological hallmarks of senile dementia of the Alzheimer type (SDAT). In 14 patients affected with SDAT (over 74 years of age), thioflavine S, Tau and acetylcholinesterase (AChE) stainings demonstrated an increased density of SP in the outer two thirds of the dentate gyrus molecular layer. However, a wide range of SP density was observed among the cases. The molecular layer of the dentate gyrus is one of the termination site of the perforant pathway that originates in layers II and III of the entorhinal cortex. We have found that the number of AChE-, thioflavine S- and Tau-positive SP that accumulate in the dentate gyrus is positively correlated with the density of thioflavine S-stained neurofibrillary tangles in layers II and III of the entorhinal cortex. In contrast, a similar correlation is not found when using Tau immunolabeling of the entorhinal tangles. These observations show an association between the accumulation of AChE-positive SP in the dentate molecular layer and the lesions of the perforant pathway. Furthermore, they suggest that the density of SP in the dentate gyrus correlates with the late stages of neurofibrillary tangles formation (thioflavine S positive), but not with the early stages (Tau positive).
老年斑（SP）是阿尔茨海默型老年性痴呆（SDAT）的神经病理学特征之一。在14例患有SDAT（年龄超过74岁）的患者中，硫黄素S、Tau和乙酰胆碱酯酶（AChE）染色显示齿状回分子层外三分之二区域的SP密度增加。然而，各病例之间观察到SP密度存在很大差异。齿状回分子层是起源于内嗅皮质第II和III层的穿通通路的终止部位之一。我们发现，在齿状回中积累的AChE、硫黄素S和Tau阳性SP的数量与内嗅皮质第II和III层中硫黄素S染色的神经原纤维缠结密度呈正相关。相比之下，对内嗅缠结进行Tau免疫标记时未发现类似的相关性。这些观察结果表明齿状分子层中AChE阳性SP的积累与穿通通路的病变之间存在关联。此外，它们表明齿状回中SP的密度与神经原纤维缠结形成的晚期阶段（硫黄素S阳性）相关，但与早期阶段（Tau阳性）无关。
