Universitat de València.
Psicothema. 2019 Aug;31(3):305-310. doi: 10.7334/psicothema2019.40.
Semantic inhibition is often found to be impaired in Alzheimer´s disease (AD). The sentence completion task (Hayling test) was used to investigate whether it would be useful for differentiating mild AD from moderate AD.
Latency responses and error scores in the automatic and inhibition parts of the test were registered in these two groups of patients and in a group of healthy older participants. The types of errors were also analysed. Group differences were analysed by ANOVA. In addition, relationships with other neuropsychological tests were reported.
Participants with moderate AD performed worse than controls in both the automatic and inhibition sections, whereas participants with mild AD exhibited impaired performance in the inhibition part, but not in the automatic part. Differences between the groups with mild and moderate AD appeared only in the error scores in the inhibition part, specifically type 3 errors. Error scores in the inhibition part correlated with performance in verbal fluency and working memory tests.
The Hayling task may be a useful tool for investigating control of inhibition in different stages of AD because different patterns of responses were observed.
语义抑制在阿尔茨海默病（AD）中常被发现受损。句子完成任务（Hayling 测试）被用于研究其是否有助于区分轻度 AD 和中度 AD。
在这两组患者和一组健康老年参与者中，记录了测试的自动和抑制部分的潜伏期反应和错误分数。还分析了错误类型。通过方差分析分析了组间差异。此外，还报告了与其他神经心理学测试的关系。
中度 AD 参与者在自动和抑制两个部分的表现均不如对照组，而轻度 AD 参与者在抑制部分表现受损，但在自动部分没有。轻度和中度 AD 组之间的差异仅出现在抑制部分的错误分数中，特别是 3 型错误。抑制部分的错误分数与言语流畅性和工作记忆测试的表现相关。
Hayling 任务可能是一种有用的工具，用于研究 AD 不同阶段的抑制控制，因为观察到了不同的反应模式。
