影响范围：系统解码微生物化学通讯
mSphere of Influence: Systematically Decoding Microbial Chemical Communication.
机构信息
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
出版信息
mSphere. 2019 Jul 10;4(4):e00319-19. doi: 10.1128/mSphere.00319-19.
Laura A. Mike works in the field of bacterial pathogenesis. In this mSphere of Influence article, she reflects on how "Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters" by P. Cimermancic et al. (Cell 158:412-421, 2014, https://doi.org/10.1016/j.cell.2014.06.034) and "A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics" by M. S. Donia et al. (Cell 158:1402-1414, 2014, https://doi.org/10.1016/j.cell.2014.08.032) made an impact on her by systematically identifying microbiome-associated biosynthetic gene clusters predicted to synthesize secondary metabolites, which may facilitate interspecies interactions.
劳拉·迈克（Laura A. Mike）从事细菌发病机制领域的工作。在本期《mSphere 影响力》文章中，她对 P. Cimermancic 等人的“从原核生物合成基因簇的全球分析看二次代谢产物的见解”（Cell 158:412-421, 2014, https://doi.org/10.1016/j.cell.2014.06.034）和 M. S. Donia 等人的“人类微生物组中生物合成基因簇的系统分析揭示了一类常见的抗生素”（Cell 158:1402-1414, 2014, https://doi.org/10.1016/j.cell.2014.08.032）进行了反思。这两篇文章通过系统地鉴定微生物组相关的生物合成基因簇，预测合成了可能促进种间相互作用的次生代谢物，对她产生了影响。
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