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影响范围:宿主防御细菌性肺炎过程中的腺苷——是敌是友?

mSphere of Influence: Adenosine in Host Defense against Bacterial Pneumonia-Friend or Foe?

机构信息

Department of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, New York, USA

出版信息

mSphere. 2019 Jul 10;4(4):e00326-19. doi: 10.1128/mSphere.00326-19.

DOI:10.1128/mSphere.00326-19
PMID:31292232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6620376/
Abstract

Elsa N. Bou Ghanem works in the field of innate immune senescence, inflammation, and host defense. In this mSphere of Influence article, she reflects on how "Adenosine A receptor deficiency promotes host defenses against Gram-negative bacterial pneumonia" by Barletta et al. (K. E. Barletta, R. E. Cagnina, M. D. Burdick, J. Linden, and B. Mehrad, Am J Respir Crit Care Med 186:1044-1050, 2012, https://doi.org/10.1164/rccm.201204-0622OC) impacted her own work examining the role of the extracellular adenosine pathway in neutrophil responses and host defense against pneumococcal pneumonia.

摘要

埃尔莎·N·布甘尼在先天免疫衰老、炎症和宿主防御领域工作。在本期《mSphere》影响力文章中,她反思了巴雷塔等人的研究成果“Adenosine A receptor deficiency promotes host defenses against Gram-negative bacterial pneumonia”(《腺苷 A 受体缺失促进宿主防御革兰氏阴性菌性肺炎》)(K. E. Barletta, R. E. Cagnina, M. D. Burdick, J. Linden, and B. Mehrad, Am J Respir Crit Care Med 186:1044-1050, 2012, https://doi.org/10.1164/rccm.201204-0622OC)如何影响她自己的工作,即研究细胞外腺苷途径在中性粒细胞反应和宿主防御肺炎链球菌性肺炎中的作用。

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本文引用的文献

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PLoS Pathog. 2018 Apr 27;14(4):e1007022. doi: 10.1371/journal.ppat.1007022. eCollection 2018 Apr.
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Bacterial-Host Interactions: Physiology and Pathophysiology of Respiratory Infection.细菌-宿主相互作用:呼吸感染的生理学和病理生理学。
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Unfolding Role of a Danger Molecule Adenosine Signaling in Modulation of Microbial Infection and Host Cell Response.腺嘌呤核苷信号在调节微生物感染和宿主细胞反应中的作用。
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Neutrophils as Components of Mucosal Homeostasis.中性粒细胞作为黏膜稳态的组成部分。
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Purinergic Signaling During Immune Cell Trafficking.嘌呤能信号在免疫细胞迁移中的作用。
Trends Immunol. 2016 Jun;37(6):399-411. doi: 10.1016/j.it.2016.04.004. Epub 2016 Apr 30.
6
Ecto-5'-nucleotidase CD73 modulates the innate immune response to influenza infection but is not required for development of influenza-induced acute lung injury.胞外5'-核苷酸酶CD73调节对流感感染的先天免疫反应,但对于流感诱导的急性肺损伤的发展并非必需。
Am J Physiol Lung Cell Mol Physiol. 2015 Dec 1;309(11):L1313-22. doi: 10.1152/ajplung.00130.2015. Epub 2015 Oct 2.
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