Hall Caroline H T, Campbell Eric L, Colgan Sean P
Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.
Cell Mol Gastroenterol Hepatol. 2017 Jul 19;4(3):329-337. doi: 10.1016/j.jcmgh.2017.07.001. eCollection 2017 Nov.
Inflammatory responses in the intestinal mucosa inevitably result in the recruitment of neutrophils (polymorphonuclear leukocytes [PMNs]). Epithelial cells that line the mucosa play an integral role in the recruitment, maintenance, and clearance of PMNs at sites of inflammation. The consequences of such PMN-epithelial interactions often determine tissue responses and, ultimately, organ function. For this reason, there is significant interest in understanding how PMNs function in the mucosa during inflammation. Recent studies have shown that PMNs play a more significant role in molding of the immune response than previously thought. Here, we review the recent literature regarding the contribution of PMNs to the development and resolution of inflammation, with an emphasis on the role of the tissue microenvironment and pathways for promoting epithelial restitution. These studies highlight the complex nature of inflammatory pathways and provide important insight into the difficulties of treating mucosal inflammation.
肠道黏膜中的炎症反应不可避免地会导致中性粒细胞（多形核白细胞[PMN]）的募集。排列在黏膜上的上皮细胞在炎症部位PMN的募集、维持和清除过程中发挥着不可或缺的作用。这种PMN与上皮细胞相互作用的结果往往决定了组织反应，并最终决定器官功能。因此，人们对了解PMN在炎症期间在黏膜中的功能有着浓厚的兴趣。最近的研究表明，PMN在塑造免疫反应中所起的作用比以前认为的更为重要。在此，我们回顾了关于PMN对炎症发展和消退作用的最新文献，重点关注组织微环境的作用以及促进上皮修复的途径。这些研究突出了炎症途径的复杂性，并为治疗黏膜炎症的困难提供了重要的见解。
