美国国立卫生研究院资助的非人类灵长类动物移植研究的转化意义。
Translational impact of NIH-funded nonhuman primate research in transplantation.
机构信息
Duke Transplant Center, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
出版信息
Sci Transl Med. 2019 Jul 10;11(500). doi: 10.1126/scitranslmed.aau0143.
Abstract
The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP) models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary purpose of this research has been to develop new treatments for down-modulating or preventing deleterious immune responses after transplantation in human patients. Here, we discuss NIH-funded NHP studies of immune cell depletion, costimulation blockade, regulatory cell therapy, desensitization, and mixed hematopoietic chimerism that either preceded clinical trials or prevented the human application of therapies that were toxic or ineffective.
摘要
美国国立卫生研究院（NIH）长期以来一直支持使用非人类灵长类动物（NHP）模型来进行肾脏、胰腺胰岛、心脏和肺移植研究。这项研究的主要目的是开发新的治疗方法，以减缓或预防人类患者移植后有害免疫反应。在这里，我们讨论了 NIH 资助的 NHP 免疫细胞耗竭、共刺激阻断、调节性细胞治疗、脱敏和混合造血嵌合体研究，这些研究要么先于临床试验，要么阻止了那些有毒或无效的治疗方法在人类中的应用。
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