Pornputtapitak Warangkana, Pantakitcharoenkul Jaturavit, Teeranachaideekul Veerawat, Sinthiptharakoon Kitiphat, Sapcharoenkun Chaweewan, Meemuk Benchaporn
Department of Chemical Engineering, Faculty of Engineering, Mahidol University.
Department of Pharmacy, Faculty of Pharmacy, Mahidol University.
J Oleo Sci. 2019 Aug 1;68(8):699-707. doi: 10.5650/jos.ess18127. Epub 2019 Jul 10.
Nanostructured lipid carriers (NLCs) are used as alternative carriers for many different drug delivery administration routes. They are composed of both solid lipid and liquid lipid (oil content) with both influencing their structural properties. Amounts of liquid lipid in NLCs play a role in drug release. Effect of liquid lipid (oil content) on physiochemical characteristics of NLCs related to drug-release requires detailed investigation. Here, many techniques were performed to analyze the physiochemical characteristics of NLCs, especially inside the particles. γ-Oryzanol (GO)-loaded NLCs were prepared at varying solid lipid to liquid lipid ratios. Their physicochemical properties, drug release profiles, and stability studies of prepared NLCs were investigated. Oil contents in NLCs were found to play a significant role in physiochemical characteristics related to drug release and stability, and also influence the efficiency of analytical techniques such as transmission electron microscopy (TEM) and dynamic force microscopy (DFM). Moreover, x-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) gave information regarding crystallinity inside the NLCs. FTIR showed broad peaks in the range from 1184 cm to 1475 cm while XRD presented a broad curve indicated amorphous forms in NLCs. Orthorhombic lattices (β' polymorph) were also elucidated by XRD and differential scanning calorimetry (DSC).
纳米结构脂质载体（NLCs）被用作许多不同药物递送给药途径的替代载体。它们由固体脂质和液体脂质（油相成分）组成，二者都会影响其结构性质。NLCs中液体脂质的含量在药物释放中起作用。液体脂质（油相成分）对与药物释放相关的NLCs理化特性的影响需要详细研究。在此，采用了多种技术来分析NLCs的理化特性，特别是颗粒内部的特性。制备了不同固体脂质与液体脂质比例的负载γ-谷维素（GO）的NLCs。研究了所制备NLCs的理化性质、药物释放曲线和稳定性。发现NLCs中的油相成分在与药物释放和稳定性相关的理化特性中起重要作用，并且还会影响诸如透射电子显微镜（TEM）和动态力显微镜（DFM）等分析技术的效率。此外，X射线衍射（XRD）和傅里叶变换红外光谱（FTIR）提供了有关NLCs内部结晶度的信息。FTIR在1184 cm至1475 cm范围内显示出宽峰，而XRD呈现出一条宽曲线，表明NLCs为无定形形式。正交晶格（β'多晶型）也通过XRD和差示扫描量热法（DSC）得以阐明。
