Sasaki Hisashi, Kimizuka Yoshifumi, Ogata Hiraku, Okada Yosuke, Ota Shinichiro, Sano Tomoya, Watanabe Chie, Maki Yohei, Yamamoto Takayuki, Tagami Yoichi, Miyata Jun, Hayashi Nobuyoshi, Fujikura Yuji, Kawana Akihiko
Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan.
Division of Hematology, Department of Internal Medicine, National Defense Medical College, Japan.
Intern Med. 2019 Nov 1;58(21):3139-3141. doi: 10.2169/internalmedicine.3002-19. Epub 2019 Jul 10.
Dasatinib-related chylothorax is a rare adverse event, and the mechanism underlying its occurrence is still not fully understood. We herein report the case of a 73-year-old woman with chronic myeloid leukemia (CML) who developed dasatinib-related chylothorax refractory to conventional treatments, except for steroids. To the best of our knowledge, this is the first case of dasatinib-related chylothorax which was successfully controlled by combining diuretics with the Japanese herbal medicine "Goreisan." "Goreisan" is known to inhibit aquaporin channels and regulate the water flow. Our findings showed that "Goreisan" is an effective treatment option for uncontrollable dasatinib-related chylothorax.
达沙替尼相关的乳糜胸是一种罕见的不良事件，其发生机制仍未完全明确。我们在此报告一例73岁慢性髓性白血病（CML）女性患者，该患者发生了达沙替尼相关的乳糜胸，除类固醇外，对传统治疗均无效。据我们所知，这是首例通过利尿剂与日本草药“五苓散”联合使用成功控制的达沙替尼相关乳糜胸病例。已知“五苓散”可抑制水通道蛋白通道并调节水流。我们的研究结果表明，“五苓散”是治疗无法控制的达沙替尼相关乳糜胸的有效选择。
