Li Jinshan, Yang Dongyong, Lin Lanlan, Yu Liying, Chen Luyang, Lu Kaiqiang, Lan Jieli, Zeng Yiming, Xu Yuan
Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, 362000, China.
Fujian Provincial Key Laboratory of Lung Stem Cells, Quanzhou, Fujian Province, 362000, China.
J Cancer. 2024 Oct 7;15(18):6073-6085. doi: 10.7150/jca.98829. eCollection 2024.
Aquaporins (AQPs) are a subgroup of small transmembrane transporters that are distributed in various types of tissues, including the lung, kidney, heart and central nervous system. It is evident that respiratory diseases represent a significant global health concern, with a considerable number of deaths occurring worldwide. Recent researches have demonstrated that AQPs play a pivotal role in respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, acute respiratory distress syndrome (ARDS), and particularly non-small cell lung cancer (NSCLC). In the context of NSCLC, the overexpression of AQP1, AQP3, AQP4, and AQP5 has been demonstrated to facilitate tumor angiogenesis, as well as the proliferation, migration, and invasiveness of tumor cells. This review concisely explores the role of AQP family on respiratory diseases, to assess their clinical and translational significance for understanding molecular pathogenesis. However, the potential translation of AQPs biomarkers into clinical applications is promising and the understanding of the precise mechanisms influencing respiratory diseases is still ongoing. Addressing the challenges and outlining the future perspectives in AQPs development is essential for clinical progress in a concise manner.
水通道蛋白（AQPs）是一类小分子跨膜转运蛋白亚群，分布于包括肺、肾、心脏和中枢神经系统在内的各种组织中。显然，呼吸系统疾病是全球重大的健康问题，在全球导致相当数量的死亡。最近的研究表明，水通道蛋白在呼吸系统疾病中起关键作用，包括慢性阻塞性肺疾病（COPD）、哮喘、急性呼吸窘迫综合征（ARDS），尤其是非小细胞肺癌（NSCLC）。在非小细胞肺癌的背景下，已证明水通道蛋白1、水通道蛋白3、水通道蛋白4和水通道蛋白5的过表达促进肿瘤血管生成以及肿瘤细胞的增殖、迁移和侵袭。本综述简要探讨了水通道蛋白家族在呼吸系统疾病中的作用，以评估它们在理解分子发病机制方面的临床和转化意义。然而，将水通道蛋白生物标志物转化为临床应用具有前景，而对影响呼吸系统疾病的确切机制的理解仍在进行中。以简洁的方式应对挑战并概述水通道蛋白开发的未来前景对于临床进展至关重要。
