Aoshima Yoichiro, Karayama Masato, Sagisaka Shinya, Yasui Hideki, Hozumi Hironao, Suzuki Yuzo, Furuhashi Kazuki, Enomoto Noriyuki, Fujisawa Tomoyuki, Nakamura Yutaro, Inui Naoki, Suda Takafumi
Second Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.
Department of Clinical Oncology, Hamamatsu University School of Medicine, Japan.
Intern Med. 2019 Nov 15;58(22):3267-3271. doi: 10.2169/internalmedicine.3032-19. Epub 2019 Jul 10.
A 69-year-old man developed bilateral polyarthritis, edematous extremities, and skin desquamation on the fingers and ears. He did not meet the criteria for any connective tissue disease, including rheumatoid arthritis. An examination revealed advanced lung cancer. His systemic manifestations were attributed to paraneoplastic Bazex syndrome and remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome. Treatment with pembrolizumab (an anti-programmed death-1 antibody) for lung cancer relieved his symptoms and shrank the lung tumor. Bazex and RS3PE syndromes are rare paraneoplastic diseases. We herein report this unique case of synchronous development of these two paraneoplastic syndromes in the presence of advanced lung cancer.
一名69岁男性出现双侧多关节炎、四肢水肿以及手指和耳部皮肤脱屑。他不符合任何结缔组织病的诊断标准，包括类风湿关节炎。检查发现患有晚期肺癌。其全身表现归因于副肿瘤性巴泽克斯综合征和缓解型血清阴性对称性滑膜炎伴凹陷性水肿（RS3PE）综合征。使用派姆单抗（一种抗程序性死亡-1抗体）治疗肺癌缓解了他的症状并使肺部肿瘤缩小。巴泽克斯综合征和RS3PE综合征是罕见的副肿瘤性疾病。我们在此报告这例在晚期肺癌情况下这两种副肿瘤性综合征同步发生的独特病例。
