Ohara Gen, Uchiyama Masahiro, Sakurai Hirofumi, Saito Sachie, Hayashi Shigen, Satoh Hiroaki
Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Mito, Ibaraki, Japan.
Division of General Medicine, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Mito, Japan.
Maedica (Bucur). 2023 Mar;18(1):143-147. doi: 10.26574/maedica.2023.18.1.143.
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome develops in patients with various underlying diseases. The involvement of vascular endothelial growth factor in the development of this syndrome has been suggested and malignant disease could be one of the underlying diseases of RS3PE syndrome. This syndrome is interpreted as one of the paraneoplastic syndromes that often have a poor prognosis. There have been few reports of lung cancer patients who developed RS3PE syndrome, and the prognosis of these patients has been rarely discussed. The present case report describes a very elderly lung cancer patient with RS3PE syndrome. We believe he is the oldest patient with advanced lung cancer to have developed RS3PE syndrome. Edema of the dorsum of both hands disappeared by one month after the start of first-line chemotherapy. The relatively long disease control period of the first and later lines of chemotherapy led to a long-term survival of 45 months. The existence of a patient with such a slow clinical course should be considered valuable for future research. It is important to continue optimal treatment even in elderly patients with RS3PE syndrome, one of the paraneoplastic syndromes.
缓解性血清阴性对称性滑膜炎伴凹陷性水肿（RS3PE）综合征可发生于患有各种基础疾病的患者。血管内皮生长因子参与该综合征的发生已被提出，恶性疾病可能是RS3PE综合征的基础疾病之一。该综合征被解释为通常预后较差的副肿瘤综合征之一。肺癌患者发生RS3PE综合征的报道很少，且这些患者的预后很少被讨论。本病例报告描述了一名患有RS3PE综合征的高龄肺癌患者。我们认为他是发生RS3PE综合征的年龄最大的晚期肺癌患者。一线化疗开始后1个月，双手背部水肿消失。一线及后续化疗相对较长的疾病控制期使患者获得了45个月的长期生存。存在这样临床病程缓慢的患者对未来研究应具有重要价值。即使对于患有RS3PE综合征（一种副肿瘤综合征）的老年患者，继续进行最佳治疗也很重要。
