Murphy D, Todd J
J Pediatr. 1979 Jun;94(6):983-7. doi: 10.1016/s0022-3476(79)80244-9.
Six soft tissue infections (three epiglottitis, one cellulitis, one pneumonia, and one arthritis) with ampicillin-resistant Haemophilus influenzae were treated initially with high doses of ampicillin (200 to 400 mg/kg/day intravenously) alone and had good clinical responses. All had documented bacteremia with H. influenzae. One child was treated only with ampicillin; treatment in the remainder was changed to oral therapy with other antibiotics to facilitate discharge. There was no recurrence of disease. Disc diffusion studies done on clinical isolates of both resistant and sensitive organisms indicate a break point at which the resistant organism shows progressive sensitivity to increasingly higher concentrations of ampicillin.
6例由耐氨苄西林的流感嗜血杆菌引起的软组织感染（3例会厌炎、1例蜂窝织炎、1例肺炎和1例关节炎）最初仅静脉给予高剂量氨苄西林（200至400mg/kg/天）治疗，临床反应良好。所有病例均记录有流感嗜血杆菌菌血症。1名儿童仅接受氨苄西林治疗；其余患儿改为口服其他抗生素以便出院。疾病无复发。对耐药和敏感菌株的临床分离株进行的纸片扩散试验表明，存在一个断点，在此断点处耐药菌株对浓度越来越高的氨苄西林逐渐表现出敏感性。
