[吸入性乙醛中毒中前列腺素及其前体的代谢]
[Metabolism of prostaglandins and their precursors in inhalational acetaldehyde poisoning].
作者信息
Buko V U, Ostrovskiĭ Iu M
出版信息
Farmakol Toksikol. 1988 Jan-Feb;51(1):83-5.
PMID:3129305
Abstract
Rats were kept for 10 days (8 hours per day) in a chamber where acetaldehyde vapour concentration was 2.5-3.0 g/m3. The animal liver levels of prostaglandins E2 and F2 alpha decreased, the activities of linoleoyl CoA desaturase and PG synthetases reduced. The content of arachidonic acid in the total lipid fraction increased. The decrease of PG synthesis under chronic alcoholic intoxication is supposed to be implemented through two mechanisms, one of which is acetaldehyde-mediated.
摘要
将大鼠置于乙醛蒸汽浓度为2.5 - 3.0克/立方米的舱室内饲养10天（每天8小时）。动物肝脏中前列腺素E2和F2α的水平降低，亚油酰辅酶A去饱和酶和PG合成酶的活性降低。总脂质部分中花生四烯酸的含量增加。慢性酒精中毒时PG合成的减少被认为是通过两种机制实现的，其中一种是乙醛介导的。
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