Nagaraja N, Talwar Pankaj, Mukherjee Bhaskar, Chakrabarty Barun Kumar
Department of ART, 151 Base Hospital, Guwahati, Assam, India.
Department of ART, AH (R and R), New Delhi, India.
J Hum Reprod Sci. 2019 Apr-Jun;12(2):136-140. doi: 10.4103/jhrs.JHRS_115_18.
Premature luteinization (PL) is defined as a premature rise in serum progesterone concentration on or before the day of ovulation trigger with human chorionic gonadotropin. The incidence of PL varies between 5% and 30% during fertilization and embryo transfer (IVF-ET).
The prospective observational study comprising 380 patients undergoing IVF-ET. Blood samples were collected for serum progesterone level estimation on the day of ovulation trigger. Ovum pickup was done 36 h later and serum progesterone levels were correlated with IVF-ET outcome.
To correlate serum progesterone level on the day of ovulation trigger during IVF and its effect on treatment outcome.
Mean serum progesterone level in the positive pregnancy group and negative pregnancy group was 0.892 ± 0.752 ng/ml and 0.91 ± 0.688 ng/ml, respectively ( = 0.961). The overall incidence of PL was 12.8% with 12.7% and 13.6% in the agonist and antagonist protocol respectively ( = 0.9001). PL incidence was 13.5% and 13.4% in positive pregnancy and negative pregnancy group ( = 0.223).
PL has been associated with 12.8% of the IVF cycles. There was no statistically significant difference observed in the incidence of PL between different IVF stimulation protocols. PL does not seem to affect IVF outcome.
过早黄素化（PL）定义为在使用人绒毛膜促性腺激素触发排卵当天或之前血清孕酮浓度过早升高。在体外受精-胚胎移植（IVF-ET）过程中，PL的发生率在5%至30%之间。
这项前瞻性观察性研究纳入了380例行IVF-ET的患者。在触发排卵当天采集血样以评估血清孕酮水平。36小时后进行取卵，并将血清孕酮水平与IVF-ET结局相关联。
为了关联IVF期间触发排卵当天的血清孕酮水平及其对治疗结局的影响。
妊娠阳性组和妊娠阴性组的平均血清孕酮水平分别为0.892±0.752 ng/ml和0.91±0.688 ng/ml（P = 0.961）。PL的总体发生率为12.8%，激动剂方案组和拮抗剂方案组分别为12.7%和13.6%（P = 0.9001）。妊娠阳性组和妊娠阴性组的PL发生率分别为13.5%和13.4%（P = 0.223）。
PL与12.8%的IVF周期相关。不同IVF刺激方案之间PL的发生率没有统计学上的显著差异。PL似乎不影响IVF结局。
