羟基导向的炔烃高区域和立体选择性氢羧化反应
Hydroxy group-enabled highly regio- and stereo-selective hydrocarboxylation of alkynes.
作者信息
Huang Chaofan, Qian Hui, Zhang Wanli, Ma Shengming
机构信息
Research Center for Molecular Recognition and Synthesis , Department of Chemistry , Fudan University , 220 Handan Lu , Shanghai 200433 , P. R. China . Email:
State Key Laboratory of Organometallic Chemistry , Shanghai Institute of Organic Chemistry , Chinese Academy of Sciences , 345 Lingling Lu , Shanghai 200032 , P. R. China . Email:
出版信息
Chem Sci. 2019 Apr 17;10(21):5505-5512. doi: 10.1039/c8sc05743e. eCollection 2019 Jun 7.
Here we present an example of utilizing hydroxy groups for regioselectivity control in the addition reaction of alkynes-a highly efficient Pd-catalyzed -hydrocarboxylation of readily available 2-alkynylic alcohols with CO in the presence of alcohols with an unprecedented regioselectivity affording 3-hydroxy-2()-alkenoates. The role of the hydroxy group has been carefully studied. The synthetic potential of the products has also been demonstrated.
在此，我们展示了一个利用羟基来控制炔烃加成反应区域选择性的例子——在醇存在下，钯催化易得的2-炔醇与一氧化碳进行高效的区域选择性氢羧化反应，生成3-羟基-2（）-链烯酸酯。我们已仔细研究了羟基的作用。同时也展示了产物的合成潜力。
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