通过对映选择性过渡金属催化构建无环季碳立体中心
Acyclic Quaternary Carbon Stereocenters via Enantioselective Transition Metal Catalysis.
作者信息
Feng Jiajie, Holmes Michael, Krische Michael J
机构信息
Department of Chemistry, Welch Hall (A5300), University of Texas at Austin , 105 East 24th Street, Austin, Texas 78712, United States.
出版信息
Chem Rev. 2017 Oct 11;117(19):12564-12580. doi: 10.1021/acs.chemrev.7b00385. Epub 2017 Sep 14.
Abstract
Whereas numerous asymmetric methods for formation of quaternary carbon stereocenters in cyclic systems have been documented, the construction of acyclic quaternary carbon stereocenters with control of absolute stereochemistry remains a formidable challenge. This Review summarizes enantioselective methods for the construction of acyclic quaternary carbon stereocenters from achiral or chiral racemic reactants via transition metal catalysis.
摘要
尽管已经有大量关于在环状体系中形成季碳立体中心的不对称方法的文献报道，但构建具有绝对立体化学控制的非环状季碳立体中心仍然是一项艰巨的挑战。本综述总结了通过过渡金属催化从未手性或手性外消旋反应物构建非环状季碳立体中心的对映选择性方法。
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