Syed Sadaf, Hakim Tajamul, Riyaz Mohd Rameez, Bedi Ravinder Singh
Department of Oral and Maxillofacial Surgery, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, India.
Department of Oral and Maxillofacial Surgery, Govt. Dental College and Hospital, Srinagar, India.
Ann Maxillofac Surg. 2019 Jan-Jun;9(1):89-95. doi: 10.4103/ams.ams_273_18.
This study aims to evaluate the efficiency of dexmedetomidine in atomized intranasal form for sedation in minor oral surgical procedures.
A total 25 patients fitting the inclusion and exclusion criteria were selected from the outpatient Department of Oral and Maxillofacial Surgery, Saraswati Dental College and Hospital, Lucknow. The drug was administered intranasally half an hour before the surgical procedure. The volume of drug used was recorded. The readings of all the parameters of sedation began 30 min after the drug had been administered. Intranasal sedation status was assessed by Ramsay sedation score and observer's assessment of alertness/sedation scales, every 15 min throughout the procedure.
The primary outcome variable in this study is depth of sedation produced by intranasally administered dexmedetomidine. Secondary variables included respiratory rate, blood pressure (BP), heart rate (HR), and oxygen saturation (SpO). The statistical software used was SPSS 20.0 for Windows (SPSS, Chicago, IL, USA). Data were expressed as mean and standard deviation or number (percentages). Sedation and behavior scores were analyzed by proportions. Hemodynamic variables including HR, SpO, and BP and respiratory rate were analyzed by repeated measures ANOVA. When a significant result was obtained, the Tukey test was applied for pairwise comparisons. < 0.05 was considered as statistically significant. All the parameters were recorded at a set interval of time.
In conclusion, intranasal administration of 1.5 mg/kg atomized dexmedetomidine was clinically effective, convenient, and safe for the sedation of patients undergoing minor oral surgical procedures.
本研究旨在评估雾化鼻内给予右美托咪定用于小型口腔外科手术镇静的效果。
从勒克瑙市萨拉斯瓦蒂牙科学院及医院口腔颌面外科门诊选取25例符合纳入及排除标准的患者。在手术前半小时经鼻给予药物。记录所用药物的体积。在给药30分钟后开始记录所有镇静参数。在整个手术过程中，每15分钟通过拉姆齐镇静评分和观察者对警觉/镇静量表的评估来评估鼻内镇静状态。
本研究的主要结局变量是经鼻给予右美托咪定产生的镇静深度。次要变量包括呼吸频率、血压（BP）、心率（HR）和血氧饱和度（SpO）。使用的统计软件是Windows版的SPSS 20.0（SPSS，美国伊利诺伊州芝加哥）。数据以均值和标准差或例数（百分比）表示。镇静和行为评分采用比例分析。包括HR、SpO、BP和呼吸频率在内的血流动力学变量采用重复测量方差分析。当获得显著结果时，应用Tukey检验进行两两比较。P<0.05被认为具有统计学意义。所有参数均在设定的时间间隔记录。
总之，经鼻给予1.5mg/kg雾化右美托咪定对接受小型口腔外科手术的患者进行镇静在临床是有效、方便且安全的。
