经鼻雾化右美托咪定在拔除下颌阻生第三磨牙手术中镇静的疗效：一项前瞻性研究
Efficacy of Intranasal Atomized Dexmedetomidine for Sedation in Surgical Removal of Impacted Mandibular Third Molars: A Prospective Study.
作者信息
Bhargavi Marupaka, Sai Sarath Gangisetty, Surana Pratik, Dhull Kanika S, Shaikh Maheen, Rajan Milind
机构信息
Department of Oral and Maxillofacial Surgery, Panineeya Institute of Dental Sciences and Research Centre, Hyderabad, IND.
Department of Pedodontics and Preventive Dentistry, Maitri College of Dentistry and Research Centre, Durg, IND.
出版信息
Cureus. 2023 Mar 26;15(3):e36721. doi: 10.7759/cureus.36721. eCollection 2023 Mar.
AIMS AND OBJECTIVES
To assess the efficacy of dexmedetomidine atomized intranasally for sedation during surgical removal of impacted mandibular third molars.
MATERIALS AND METHODS
A prospective randomized trial was conducted on 25 anxious patients between the ages of 18 and 40 who had impacted the lower third molars. An intranasal atomization device was used to give the medication 30 minutes prior to the surgical procedure. The Ramsay sedation score and Observer's assessment of alertness/sedation score were used to assess intranasal sedation.
RESULTS
The results of our study state that the sedative effect began to take effect between 30 and 45 minutes later and was nearly back to baseline by 105 minutes after the administration of intranasal dexmedetomidine.
CONCLUSION
Intranasal delivery of 1.5mg/kg atomized dexmedetomidine for patients undergoing surgical removal of impacted mandibular third teeth is safe, feasible, and clinically efficient in daycare settings based on the sedation scores, and secondary variables which were assessed.
目的
评估右美托咪定经鼻雾化用于下颌阻生第三磨牙拔除术中镇静的疗效。
材料与方法
对25例年龄在18至40岁之间、下颌第三磨牙阻生的焦虑患者进行了一项前瞻性随机试验。在手术前30分钟使用鼻内雾化装置给药。采用Ramsay镇静评分和观察者警觉/镇静评分来评估经鼻镇静效果。
结果
我们的研究结果表明，镇静作用在给药后30至45分钟开始起效，在经鼻给予右美托咪定105分钟后几乎恢复到基线水平。
结论
根据镇静评分以及所评估的次要变量，对于接受下颌阻生第三磨牙拔除术的患者，经鼻给予1.5mg/kg雾化右美托咪定在日间手术环境中是安全、可行且临床有效的。
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