CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
Center of Materials Science and Optoelectronics, University of Chinese Academy of Sciences, Beijing, 100049, China.
Chemistry. 2019 Oct 22;25(59):13452-13457. doi: 10.1002/chem.201902501. Epub 2019 Aug 28.
The past several decades have witnessed a rapid revolution of DNA nanotechnology. DNA nanostructures are mainly synthesized with two approaches, by assembly of purely DNA-based nanostructures through complementary base pairing or grafting DNA onto nanoparticles (NPs). Despite the progress made, developing simple and universal methods for the synthesis of DNA nanoarchitectures with specific morphologies and functionalities is still a challenge. This article introduces the reader to a new biomimetic methodology that leads to the controlled synthesis of DNA nanoarchitectures based on metal-DNA coordination chemistry and, furthermore, demonstrates the broad biomedical applications of these functional materials. In particular, we highlight the coordination-driven 1) surface-functionalization of NPs with DNA molecules and 2) direct self-assembly of metal-DNA nanostructures. Finally, challenges and opportunities of this approach to develop nanobiotechnology are provided.
过去几十年见证了 DNA 纳米技术的快速革命。DNA 结构主要通过两种方法合成，通过互补碱基配对组装纯基于 DNA 的纳米结构，或在纳米粒子 (NPs) 上接枝 DNA。尽管取得了进展，但开发具有特定形态和功能的 DNA 纳米结构的简单通用合成方法仍然是一个挑战。本文向读者介绍了一种新的仿生方法，该方法可以通过金属-DNA 配位化学来控制 DNA 纳米结构的合成，并进一步展示了这些功能材料在广泛的生物医学中的应用。特别是，我们强调了配位驱动的 1）NPs 与 DNA 分子的表面功能化和 2）金属-DNA 纳米结构的直接自组装。最后，提供了这种开发纳米生物技术的方法的挑战和机遇。
