CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Angew Chem Int Ed Engl. 2019 Jan 28;58(5):1350-1354. doi: 10.1002/anie.201810735. Epub 2018 Dec 21.
Developing simple and general approaches for the synthesis of nanometer-sized DNA materials with specific morphologies and functionalities is important for various applications. Herein, a novel approach for the synthesis of a new set of DNA-based nanoarchitectures through coordination-driven self-assembly of Fe ions and DNA molecules is reported. By fine-tuning the assembly, Fe-DNA nanospheres of precise sizes and controlled compositions can be produced. The hybrid nanoparticles can be tailored for delivery of functional DNA to cells in vitro and in vivo with enhanced biological function. This highlights the potential of metal ion coordination as a tool for directing the assembly of DNA architectures, which conceptualizes a new pathway to expand the repertoire of DNA-based nanomaterials. This methodology will advance both the fields of DNA nanobiotechnology and metal-ligand coordination chemistry.
开发简单通用的方法来合成具有特定形貌和功能的纳米级 DNA 材料对于各种应用非常重要。本文报道了一种通过 Fe 离子和 DNA 分子的配位驱动自组装来合成一组新型 DNA 纳米结构的新方法。通过精细调控组装，可以制备具有精确尺寸和可控组成的 Fe-DNA 纳米球。这些杂化纳米颗粒可以被定制用于将功能性 DNA 递送到体外和体内的细胞中，并增强其生物学功能。这凸显了金属离子配位作为指导 DNA 结构组装的工具的潜力，为扩展基于 DNA 的纳米材料的范围提供了新途径。该方法将推进 DNA 纳米生物技术和金属配体配位化学两个领域的发展。
