Division of Diabetes and Nutritional Sciences, Faculty of Life Sciences and Medicine , King's College London , 150 Stamford Street , London SE1 9NH , United Kingdom.
Mars, Incorporated , 6885 Elm Street , McLean , Virginia 22101 , United States.
J Agric Food Chem. 2020 Feb 19;68(7):1871-1876. doi: 10.1021/acs.jafc.9b02251. Epub 2019 Aug 12.
Cocoa flavanols (CFs) can improve flow-mediated dilation (FMD), blood pressure, and vascular stiffness in healthy subjects. Endothelial microparticles (EMPs) are markers of endothelial functional integrity, reflecting activation and injury. In plasma samples, we investigated whether age-dependent changes in circulating EMPs exist and whether CFs decrease EMPs in healthy humans. The concentrations of CD31/41, CD144, and CD62e EMPs (flow cytometry) were increased in healthy elderly ( = 19) compared to young ( = 20) non-smokers. EMPs correlated with age, systolic blood pressure, and pulse wave velocity. CD31/41 and CD62e EMPs inversely correlated with FMD. Following 2 weeks twice-daily CF consumption (450 mg), CD31/41 and CD144 EMPs decreased in both young and elderly subjects compared to the CF-free control. The EMP decrease inversely correlated with FMD improvements. Cardiovascular aging is associated with increased EMPs that can be modulated by dietary flavanols along with improvements in vascular function. This indicates that flavanol consumption can improve endothelial functional integrity in healthy humans.
可可黄烷醇（CFs）可改善健康受试者的血流介导扩张（FMD）、血压和血管僵硬。内皮细胞微颗粒（EMPs）是内皮功能完整性的标志物，反映了激活和损伤。在血浆样本中，我们研究了循环 EMPs 是否存在年龄相关性变化，以及 CFs 是否会减少健康人群中的 EMPs。与年轻（=20）非吸烟者相比，健康老年人（=19）的 CD31/41、CD144 和 CD62e EMPs（流式细胞术）浓度增加。EMPs 与年龄、收缩压和脉搏波速度相关。CD31/41 和 CD62e EMPs 与 FMD 呈负相关。在 2 周内每天两次 CF 摄入（450mg）后，与 CF 无干预对照组相比，年轻和老年受试者的 CD31/41 和 CD144 EMPs 均减少。EMP 的减少与 FMD 的改善呈负相关。心血管衰老与 EMPs 的增加有关，而饮食黄烷醇可调节 EMPs，同时改善血管功能。这表明黄烷醇的摄入可以改善健康人群的内皮功能完整性。
