Budnik V, White K
Biophysics Program, Brandeis University, Waltham, Massachusetts 02254.
J Comp Neurol. 1988 Feb 15;268(3):400-13. doi: 10.1002/cne.902680309.
The development of catecholamine-containing neurons (CA neurons) in the fruit fly Drosophila melanogaster was studied. Glyoxylic-acid-induced histofluorescence and antibodies against dopamine and tyrosine hydroxylase were used to describe catecholamine distribution in the larval central nervous system (CNS). The three techniques gave rise to a similar pattern of distribution of putative CA neurons. At all developmental stages CA neurons were distributed widely throughout the CNS but represented only a small fraction of all CNS neurons. Catecholamine-containing processes were confined to the CNS. The CA neurons are first discerned at about 18 hours of embryonic development. We suggest that these larval CA neurons are maintained throughout the ontogeny of the fly and that the adult CA pattern is composed of embryonic neurons and neurons that differentiate during metamorphosis.
对果蝇黑腹果蝇中含儿茶酚胺神经元（CA神经元）的发育进行了研究。采用乙醛酸诱导的组织荧光以及抗多巴胺和酪氨酸羟化酶的抗体来描述幼虫中枢神经系统（CNS）中儿茶酚胺的分布。这三种技术产生了相似的假定CA神经元分布模式。在所有发育阶段，CA神经元广泛分布于整个中枢神经系统，但仅占所有中枢神经系统神经元的一小部分。含儿茶酚胺的突起局限于中枢神经系统。CA神经元在胚胎发育约18小时时首次被识别。我们认为，这些幼虫CA神经元在果蝇的整个个体发育过程中得以保留，并且成虫的CA模式由胚胎神经元和在变态过程中分化的神经元组成。
