Vallés A M, White K
Department of Biology, Brandeis University, Waltham, Massachusetts 02254.
J Comp Neurol. 1988 Feb 15;268(3):414-28. doi: 10.1002/cne.902680310.
Antibodies made against serotonin (5HT) were used to identify the serotonin neuronal system in the developing and adult nervous system of Drosophila melanogaster. The 5HT neuronal pattern is composed of a small number of neurons, 84 in larvae and 106 in adults, distributed in clusters composed of one to five neurons in the CNS; 5HT immunoreactive (5HT-IR) neurons appear to be predominantly intrasegmental interneurons; however, intersegmental 5HT-IR fibers are observed and at least some neurons send peripheral fibers. Acquisition of 5HT immunoreactivity in the CNS occurs late in embryogenesis, by 16-18 hours, and most if not all the 5HT neurons appear to persist into adulthood. During early metamorphosis, the intensity of 5HT-IR neuropil transiently decreases. Other changes in the CNS during this period are reflected in the appearance of two new 5HT clusters and 5HT-IR neuropil in the developing optic lobes. Comparison of the 5HT-IR pattern with other transmitter systems in Drosophila as well as comparison of the 5HT-IR pattern within different insect species is presented.
针对血清素（5HT）制备的抗体被用于鉴定黑腹果蝇发育中和成年神经系统中的血清素神经元系统。5HT神经元模式由少量神经元组成，幼虫中有84个，成虫中有106个，分布于中枢神经系统中由一至五个神经元组成的簇中；5HT免疫反应性（5HT-IR）神经元似乎主要是节段内中间神经元；然而，观察到了节段间5HT-IR纤维，并且至少一些神经元发出外周纤维。中枢神经系统中5HT免疫反应性的获得在胚胎发育后期，即16 - 18小时时发生，并且大多数（如果不是全部）5HT神经元似乎会持续到成年期。在变态初期，5HT-IR神经毡的强度会短暂降低。在此期间中枢神经系统的其他变化体现在发育中的视叶中出现两个新的5HT簇和5HT-IR神经毡。本文还介绍了果蝇中5HT-IR模式与其他递质系统的比较以及不同昆虫物种间5HT-IR模式的比较。
