Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Fundus Diseases, Shanghai, China.
Curr Eye Res. 2019 Dec;44(12):1299-1305. doi: 10.1080/02713683.2019.1641827. Epub 2019 Jul 15.
: To compare the prevalence of dry eye disease between children with and without diabetes, and analyze the factors associated with dry eye disease in children with diabetes.: 38 children with diabetes were selected as cases, and 40 children without diabetes constituted the control group. The prevalence of dry eye disease in both groups was statistically analyzed. Related factors of dry eye disease were analyzed in children with diabetes.: The prevalence of dry eye disease in the case group was significantly higher than that in the control group ( < .01), with the attributable proportion among the exposed (0.827) and the population attributable fraction (0.700). Univariate analysis showed that the diabetes duration, best-corrected visual acuity, corneal sensation, and levels of glycosylated hemoglobin were associated with dry eye disease in children with diabetes. Logistic regression analysis revealed that only diabetes duration and corneal sensation were independent factors associated with dry eye disease. The diabetes duration was significantly higher and the level of corneal sensation was significantly lower in subjects with dry eye disease than in those without dry eye disease.: Early screening and close follow-up of dry eye disease in children with diabetes should be strictly implemented, especially in children with a long duration of diabetes and those with peripheral neuropathy.
比较糖尿病儿童与非糖尿病儿童干眼症的患病率，分析糖尿病儿童干眼症的相关因素。方法：选取糖尿病儿童 38 例作为病例组，同期选取非糖尿病儿童 40 例作为对照组，统计分析两组干眼症的患病情况，并对糖尿病儿童干眼症的相关因素进行分析。结果：病例组干眼症的患病率显著高于对照组（<0.01），其归因危险度（0.827）及人群归因危险度（0.700）均较高。单因素分析显示，糖尿病病程、最佳矫正视力、角膜知觉、糖化血红蛋白水平与糖尿病儿童干眼症有关。Logistic 回归分析显示，仅糖尿病病程和角膜知觉是糖尿病儿童干眼症的独立相关因素。干眼症组的糖尿病病程显著长于无干眼症组，角膜知觉显著低于无干眼症组。结论：应严格对糖尿病儿童进行干眼症的早期筛查和密切随访，尤其对糖尿病病程较长及合并周围神经病变的患儿。
