Endocrine Research Center (Firouzgar), Institute of Endocrinology and Metabolism, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
J Diabetes Complications. 2013 Sep-Oct;27(5):459-62. doi: 10.1016/j.jdiacomp.2013.04.006. Epub 2013 May 30.
This study was performed to investigate the correlation between dry eye disease and diabetes microvascular complications.
In this study 243 people with type 2 diabetes were enrolled. Tear osmolarity was measured using tear lab osmolarity system. All of the participants were evaluated for diabetes microvascular complications. The Michigan neuropathy screening instrument was used for detection of peripheral neuropathy, and the albumin/creatinine ratio in a spot urine sample was considered to diagnose diabetic nephropathy.
The prevalence of dry eye disease was 27.7%. The mean value for tear osmolarity was 301.97±13.52 mOsm/L. We found a significant correlation between dry eye disease and diabetic retinopathy (P=0.01). However no significant correlation was found between dry eye disease, diabetic neuropathy, and diabetic nephropathy. Dry eye disease was more prevalent in people with proliferative diabetic retinopathy and/or clinically significant macular edema (0.006). In a binary logistic regression analysis model, there was a significant correlation between dry eye disease and retinopathy (OR=2.29, CI=1.16-4.52, P=0.016). In addition, both dry eye and retinopathy had significant correlation with HbA1C.
Dry eye disease is common in people with type 2 diabetes, especially in those with diabetic retinopathy. In addition, it is more prevalent in people who suffer from advanced stages of diabetic retinopathy.
本研究旨在探讨干眼症与糖尿病微血管并发症的相关性。
本研究纳入了 243 例 2 型糖尿病患者。使用泪液实验室渗透压系统测量泪液渗透压。所有患者均评估了糖尿病微血管并发症。采用密歇根神经病变筛查工具检测周围神经病变，尿白蛋白/肌酐比值用于诊断糖尿病肾病。
干眼症的患病率为 27.7%。平均泪液渗透压为 301.97±13.52 mOsm/L。我们发现干眼症与糖尿病性视网膜病变之间存在显著相关性（P=0.01）。然而，干眼症与糖尿病神经病变和糖尿病肾病之间无显著相关性。在增殖性糖尿病视网膜病变和/或有临床意义的黄斑水肿患者中，干眼症更为常见（0.006）。在二元逻辑回归分析模型中，干眼症与视网膜病变之间存在显著相关性（OR=2.29，CI=1.16-4.52，P=0.016）。此外，干眼症和视网膜病变均与 HbA1C 显著相关。
干眼症在 2 型糖尿病患者中较为常见，尤其是在糖尿病性视网膜病变患者中。此外，它在患有糖尿病性视网膜病变晚期的患者中更为常见。
