Ramakrishna N, Martin J G
J Natl Med Assoc. 1979 May;71(5):475-7.
The major cause of portal hypertension in Western countries is nutritional cirrhosis (parenchymal block) related to alcoholism. A third of those patients die of variceal bleeding when increased pressure within the varices precipitates bleeding. Construction of portal systemic shunts is aimed at reducing the pressure within the varices and thereby decreasing the risk of bleeding. However, it increases the incidence of hepatic encephalopathy and hence should be used only in patients who have bled. The remaining function appears to be the main factor that determines survival and the incidence of encephalopathy in obese individuals. Portacaval shunts almost completely eliminate the risk of bleeding. There is a greater incidence of hepatic encephalopathy with this procedure than with other shunts. The splenorenal shunt and the distal splenorenal shunt appear to work well in selected patients. Technically, it is a more difficult procedure. The interposition mesocaval shunt is technically easier and is also helpful in patients with ascites. Its post-shunt encephalopathy rate, however, is higher than the splenorenal shunt or the distal splenorenal shunt, though less than the portacaval shunts. Experience with the newer arterialized portacaval and coronary caval shunts is limited. A non-shunt procedure, such as the one described by Sugiura, with impressive results and follow-up may become more acceptable as experience grows.
西方国家门静脉高压的主要病因是与酒精中毒相关的营养性肝硬化(实质阻塞)。当静脉曲张内压力升高引发出血时,三分之一的此类患者死于静脉曲张破裂出血。门静脉体分流术旨在降低静脉曲张内的压力,从而降低出血风险。然而,这会增加肝性脑病的发生率,因此仅应在已出血的患者中使用。剩余肝功能似乎是决定肥胖个体生存率和肝性脑病发生率的主要因素。门腔分流术几乎完全消除了出血风险。与其他分流术相比,该手术引发肝性脑病的发生率更高。脾肾分流术和远端脾肾分流术在特定患者中似乎效果良好。从技术角度而言,这是一种更具难度的手术。间置肠系膜腔静脉分流术在技术上更简便,对腹水患者也有帮助。然而,其分流术后肝性脑病发生率高于脾肾分流术或远端脾肾分流术,不过低于门腔分流术。对于较新的动脉化门腔分流术和冠状腔静脉分流术的经验有限。一种非分流手术,例如杉浦描述的手术,随着经验的积累,其显著的效果和随访结果可能会更被接受。