Porter K A, Blackburn G L, Bistrian B R
Department of Surgery, St. Elizabeth's Hospital, Boston, Massachusetts.
J Am Coll Nutr. 1988 Apr;7(2):107-10. doi: 10.1080/07315724.1988.10720226.
Parenteral iron, in the form of intramuscular injection or intravenous infusion of iron dextran, is commonly used to treat iron deficiency. Constitutional symptoms, anaphylaxis, and rarely death are risks associated with the use of iron dextran for this purpose. However, iron supplementation of TPN solutions to meet daily requirements can be accomplished safely. We propose that iron dextran added to TPN is well tolerated by patients because the amounts employed are small and the infusion times are long. To illustrate, we present a case where rapid administration of parenteral iron was associated with allergic type symptoms. Inclusion of daily requirements of iron in the TPN solution prior to and subsequent to this reaction did not elicit symptoms.
肠胃外铁剂，以肌肉注射或静脉输注右旋糖酐铁的形式，常用于治疗缺铁。体质性症状、过敏反应，以及罕见的死亡是使用右旋糖酐铁治疗缺铁的相关风险。然而，补充肠外营养（TPN）溶液中的铁以满足每日需求可以安全地完成。我们认为添加到TPN中的右旋糖酐铁患者耐受性良好，因为使用的量小且输注时间长。为了说明这一点，我们展示一个病例，肠胃外铁剂快速给药与过敏样症状相关。在该反应之前和之后，肠外营养溶液中包含每日所需的铁并未引发症状。
