Salehpour Saghar, Nazari Leila, Hoseini Sedighe, Moghaddam Parya Bameni, Gachkar Latif
Department of Obstetrics and Gynecology, Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
JBRA Assist Reprod. 2019 Oct 14;23(4):392-395. doi: 10.5935/1518-0557.20190033.
Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age. This study investigated the effects of L-carnitine on the clinical and laboratory findings of women with PCOS.
Eighty women diagnosed with PCOS between 2017 and 2018 by the Rotterdam Criteria were enrolled in the study; six were lost during the study. The participants were given L-carnitine 3 g daily (Pursinapharma, Iran) for three months. Blood samples were taken after overnight fasting at baseline and three months into the study to assess the levels of fasting glucose, insulin, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), free testosterone, dehydroepiandrosterone (DHEA), and the insulin resistance index (HOMA-IR). The patients were weighed before and after treatment and had their body mass index (BMI) calculated. Menstrual cycles and manifestations of hirsutism were also assessed.
The data showed a significant improvement in insulin sensitivity and decreases in serum LDL levels and the BMI after three months of treatment. There was a significant increase in serum HDL levels. More regular menstrual cycles and decreased hirsutism were also observed.
It appears that treatment with L-carnitine might decrease the risk of cardiovascular events by normalizing metabolic profiles and the BMI.
多囊卵巢综合征（PCOS）是育龄期女性的常见疾病。本研究调查了左旋肉碱对PCOS女性临床及实验室检查结果的影响。
选取2017年至2018年根据鹿特丹标准诊断为PCOS的80名女性纳入研究；6名在研究期间失访。参与者每天服用3克左旋肉碱（Pursinapharma，伊朗），持续三个月。在基线期及研究进行三个月后，于空腹过夜后采集血样，以评估空腹血糖、胰岛素、甘油三酯、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、游离睾酮、脱氢表雄酮（DHEA）水平以及胰岛素抵抗指数（HOMA-IR）。在治疗前后对患者进行称重，并计算其体重指数（BMI）。还评估了月经周期和多毛症表现。
数据显示，治疗三个月后胰岛素敏感性显著改善，血清LDL水平和BMI降低。血清HDL水平显著升高。还观察到月经周期更规律且多毛症减轻。
看来左旋肉碱治疗可能通过使代谢指标和BMI正常化来降低心血管事件风险。
