Wang Dong-Dong, Li Ya-Feng, Mao Yi-Zhen, He Su-Mei, Zhu Ping, Wei Qun-Li
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou, China.
Department of Pharmacy, Feng Xian People's Hospital, Xuzhou, China.
Front Nutr. 2022 Aug 10;9:851275. doi: 10.3389/fnut.2022.851275. eCollection 2022.
The present study aimed to explore the effect of carnitine supplementation on body weight in patients with polycystic ovary syndrome (PCOS) and predict an appropriate dosage schedule using a machine-learning approach. Data were obtained from literature mining and the rates of body weight change from the initial values were selected as the therapeutic index. The maximal effect (E) model was built up as the machine-learning model. A total of 242 patients with PCOS were included for analysis. In the machine-learning model, the E of carnitine supplementation on body weight was -3.92%, the ET was 3.6 weeks, and the treatment times to realize 25%, 50%, 75%, and 80% (plateau) E of carnitine supplementation on body weight were 1.2, 3.6, 10.8, and 14.4 weeks, respectively. In addition, no significant relationship of dose-response was found in the dosage range of carnitine supplementation used in the present study, indicating the lower limit of carnitine supplementation dosage, 250 mg/day, could be used as a suitable dosage. The present study first explored the effect of carnitine supplementation on body weight in patients with PCOS, and in order to realize the optimal therapeutic effect, carnitine supplementation needs 250 mg/day for at least 14.4 weeks.
本研究旨在探讨补充肉碱对多囊卵巢综合征（PCOS）患者体重的影响，并采用机器学习方法预测合适的给药方案。数据通过文献挖掘获得，体重相对于初始值的变化率被选作治疗指标。构建最大效应（E）模型作为机器学习模型。共纳入242例PCOS患者进行分析。在机器学习模型中，补充肉碱对体重的E为-3.92%，ET为3.6周，实现补充肉碱对体重25%、50%、75%和80%（平台期）E的治疗时间分别为1.2、3.6、10.8和14.4周。此外，在本研究使用的补充肉碱剂量范围内未发现明显的剂量-反应关系，这表明补充肉碱的下限剂量250毫克/天可作为合适剂量。本研究首次探讨了补充肉碱对PCOS患者体重的影响，为实现最佳治疗效果，补充肉碱至少需要250毫克/天，持续14.4周。
