Mineral Resources Research Division, Korea Institute of Geoscience and Mineral Resources (KIGAM), Daejeon 34132, Republic of Korea; Korea University of Science and Technology, Division of Resources Recycling, Daejeon 34113, Republic of Korea.
Mineral Resources Research Division, Korea Institute of Geoscience and Mineral Resources (KIGAM), Daejeon 34132, Republic of Korea; Korea University of Science and Technology, Division of Resources Recycling, Daejeon 34113, Republic of Korea.
Int J Pharm. 2019 Aug 15;567:118502. doi: 10.1016/j.ijpharm.2019.118502. Epub 2019 Jul 8.
Montmorillonite (MMT) is a highly promising material for use in drug delivery due to its high drug loading capacity and controlled drug release properties. MMT protects drug molecules between layered structure; however, drug release from MMT is sustained less than 6 h, which is insufficient for the release of antibiotics. This study sought to synthesize an antibiotic delivery material with more sustained release properties. A ciprofloxacin (CIP)-MMT composite was fabricated using carboxymethylated nanocellulose (CMCNF). A simple adsorption reaction intercalated 31.1% of CIP molecules present into the MMT under optimized conditions (pH 5, CIP = 1000 mg/L, Reaction time = 3 h). The synthesized CIP-MMT composite was fabricated using 1.5, 2, or 3 wt% CMCNF. Increasing the CMCNF content delayed the erosion of the CMCNF matrix and prevented rapid dissolution of the CIP-MMT composite. In vitro release experiments revealed that the CIP-MMT composite material provided the sustained release of CIP over 6 h. Erosion of the 3 wt% CMCNF-CIP-MMT composite occurred slowly and provided 48 h of sustained CIP release. An anti-bacterial test revealed that the 3 wt% CMCNF-CIP-MMT composite displayed the most constant antibacterial activity over 12 days. These results demonstrated that the CMCNF prepared with CIP intercalation in MMT was highly effective in prolonging the antibiotic release.
蒙脱石（MMT）因其高载药量和控释药物特性，是一种很有前途的药物传递材料。MMT 保护药物分子在层状结构之间；然而，MMT 中的药物释放持续时间不到 6 小时，这对于抗生素的释放来说是不够的。本研究旨在合成具有更持续释放特性的抗生素传递材料。采用羧甲基化纳米纤维素（CMCNF）合成了环丙沙星（CIP）-MMT 复合材料。在优化条件下（pH5、CIP=1000mg/L、反应时间=3h），通过简单的吸附反应将 31.1%的 CIP 分子插入到 MMT 中。采用 1.5wt%、2wt%或 3wt%的 CMCNF 制备合成的 CIP-MMT 复合材料。增加 CMCNF 的含量会延迟 CMCNF 基质的侵蚀，并防止 CIP-MMT 复合材料的快速溶解。体外释放实验表明，CIP-MMT 复合材料在 6 小时以上提供了 CIP 的持续释放。3wt%CMCNF-CIP-MMT 复合材料的侵蚀缓慢，并提供了 48 小时的持续 CIP 释放。抗菌试验表明，3wt%CMCNF-CIP-MMT 复合材料在 12 天内显示出最稳定的抗菌活性。这些结果表明，用 CIP 插层 MMT 制备的 CMCNF 能有效地延长抗生素的释放。
