一种姜黄素激活的羧甲基纤维素-蒙脱石粘土纳米复合材料，在水介质中有增强的姜黄素释放。
A curcumin activated carboxymethyl cellulose-montmorillonite clay nanocomposite having enhanced curcumin release in aqueous media.
机构信息
Sri Lanka Institute of Nanotechnology (SLINTEC), Nanotechnology and Science Park, Mahenwatta, Pitipana, Homagama, Sri Lanka; Department of Engineering, University of Cambridge, Cambridge, UK.
Sri Lanka Institute of Nanotechnology (SLINTEC), Nanotechnology and Science Park, Mahenwatta, Pitipana, Homagama, Sri Lanka; Department of Chemistry, University of Colombo, Colombo 03, Sri Lanka.
出版信息
Carbohydr Polym. 2015 Dec 10;134:695-9. doi: 10.1016/j.carbpol.2015.08.030. Epub 2015 Aug 17.
A novel curcumin activated carboxymethylcellulose-montmorillonite nanocomposite is reported. A superabsorbent biopolymer; carboxymethyl cellulose (CMC) was used as an emulsifier for curcumin which is a turmeric derived water insoluble polyphenolic compound with antibacterial/anti-cancer properties. Montmorillonite (MMT) nanoclay was incorporated in the formulation as a matrix material which also plays a role in release kinetics. It was observed that water solubility of curcumin in the nanocomposite has significantly increased (60% release within 2h and 30 min in distilled water at pH 5.4) compared to pure curcumin. The prepared curcumin activated carboxymethylcellulose-montmorillonite nanocomposite is suitable as a curcumin carrier having enhanced release and structural properties.
本文报道了一种新型姜黄素激活羧甲基纤维素-蒙脱石纳米复合材料。羧甲基纤维素（CMC）是一种超吸水性生物聚合物，用作姜黄素的乳化剂，姜黄素是一种源自姜黄的不溶于水的多酚化合物，具有抗菌/抗癌特性。蒙脱土（MMT）纳米粘土被掺入配方中作为基质材料，它也在释放动力学中发挥作用。观察到纳米复合材料中姜黄素的水溶性显著增加（在 pH5.4 的蒸馏水中 2 小时内释放 60%，30 分钟内释放 30%），与纯姜黄素相比。所制备的姜黄素激活羧甲基纤维素-蒙脱石纳米复合材料适合作为具有增强释放和结构性能的姜黄素载体。
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