Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
U.O.C. Clinical Pathology AOU Sassari, Sassari, Italy.
Clin Neurophysiol. 2019 Sep;130(9):1511-1519. doi: 10.1016/j.clinph.2019.05.021. Epub 2019 Jun 10.
To provide normative data for the Vestibulo-Masseteric Reflex (VMR) and Acoustic-Masseteric Reflex (AMR) in healthy subjects, stratified for age and gender.
A total of 82 healthy subjects (M:F 43:39, mean age 39.3 ± 18.4 years, range 13-79 years) underwent recording of click-evoked VMR and AMR (0.1 ms duration, 5 Hz frequency) from active masseter muscles. Masseter responses to uni- and bilateral stimulation were recorded in a zygomatic and a mandibular configuration, according to the position of the reference electrode. Stimulation intensity curves were recorded for each reflex in ten subjects (mean age 20.7 ± 8.1 years). Gender effect was investigated in 62 subjects and age effect was analyzed in six 10-subject groups aged from <25 to >65 years. Onset and peak latencies, interpeak intervals, raw and corrected amplitudes, latency and amplitude asymmetries were analyzed.
VMR had a higher elicitation rate than AMR. For both reflexes, rates of elicitation, and corrected amplitudes were higher in the zygomatic configuration, and bilateral stimulation elicited larger responses. Best acoustic ranges of elicitation were 98-113 dB for AMR and 128-138 dB for VMR. Reflex latencies were shorter in females than males. Frequency and amplitude of VMR and AMR decreased substantially over 55 year olds.
VMR and AMR can be easily performed in any clinical neurophysiology laboratory.
These reflexes can find application in the investigation of brainstem function in central neurological disorders.
为健康受试者的前庭-咬肌反射（VMR）和听觉-咬肌反射（AMR）提供年龄和性别分层的正常参考值。
共有 82 名健康受试者（M:F 43:39，平均年龄 39.3±18.4 岁，范围 13-79 岁）接受主动咬肌的 click 诱发 VMR 和 AMR（0.1ms 时长，5Hz 频率）记录。根据参考电极的位置，以颧骨和下颌两种配置记录单刺激和双刺激的咬肌反应。在 10 名受试者（平均年龄 20.7±8.1 岁）中记录了每个反射的刺激强度曲线。在 62 名受试者中研究了性别效应，在 6 个年龄组（<25 岁至>65 岁）中分析了年龄效应。分析了起始潜伏期、峰潜伏期、峰间潜伏期、原始和校正幅度、潜伏期和幅度不对称性。
VMR 的诱发率高于 AMR。对于两种反射，诱发率和校正幅度在颧骨配置中较高，双侧刺激可诱发更大的反应。AMR 的最佳诱发声级为 98-113dB，VMR 为 128-138dB。女性的反射潜伏期比男性短。55 岁以上人群的 VMR 和 AMR 的频率和幅度明显下降。
VMR 和 AMR 可在任何临床神经生理学实验室轻松进行。
这些反射可用于研究中枢神经系统疾病中脑干功能。
