黄酮类化合物肠道代谢的化学方面

Metalloenzyme Research Group and Department of Plant Science and Technology, Chung-Ang University, Anseong 17546, Korea.

Metabolites. 2019 Jul 10;9(7):136. doi: 10.3390/metabo9070136.

The intestine is a small world where all the chemical reactions are operated by gut microbiota. Study on the gut metabolism of natural products is a new and expanding research area that leads to new bioactive metabolites, as well as novel chemical reactions. To provide exemplary cases, flavonoid biotransformation by intestinal bacteria with focus on -equol biosynthesis and aryl methyl ether cleavage reaction, is described in this review.

肠道是一个由肠道微生物群操控所有化学反应的小世界。对天然产物肠道代谢的研究是一个新的且不断拓展的研究领域，该领域会产生新的生物活性代谢产物以及新的化学反应。为提供示例，本综述描述了肠道细菌对黄酮类化合物的生物转化，重点是雌马酚的生物合成和芳基甲基醚裂解反应。