Karamitopoulou Eva, Gloor Beat
Pancreatic Cancer Research Group, Institute of Pathology, University of Bern, Murtenstrasse 31, CH-3008 Bern, Switzerland.
Department of Visceral Surgery, Insel University Hospital, University of Bern, Freiburgstrasse 18, CH-3010 Bern, Switzerland.
Cancers (Basel). 2019 Jul 10;11(7):968. doi: 10.3390/cancers11070968.
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with increasing incidence and dismal prognosis. The composition of the immune cell infiltrates in the tumor microenvironment (TME) and the dynamic interplay between cancer- and immune cells can influence and/or be influenced by tumor-intrinsic characteristics like molecular profiles and tumor cell morphology. The combined analyses of pancreatic cancer by using morphologic, genetic, and immunologic features help us understand the significant heterogeneity of the TME and recognize the different mechanisms of immune evasion. Moreover, this information may lead to the identification of novel biomarkers for more precise patient stratification and therapy guidance.
胰腺导管腺癌（PDAC）是一种发病率不断上升且预后极差的毁灭性疾病。肿瘤微环境（TME）中免疫细胞浸润的组成以及癌细胞与免疫细胞之间的动态相互作用，可受到诸如分子谱和肿瘤细胞形态等肿瘤内在特征的影响，同时也能对这些特征产生影响。通过结合形态学、遗传学和免疫学特征对胰腺癌进行综合分析，有助于我们了解TME的显著异质性，并认识到不同的免疫逃逸机制。此外，这些信息可能会促成新型生物标志物的识别，以实现更精确的患者分层和治疗指导。
